S1PR1

(redirected from sphingosine 1-phosphate receptor 1)

S1PR1

A gene on chromosome 1p21 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor, which is highly expressed in endothelial cells. It binds the sphingosine-1-phosphate with high affinity and high specificity, and may be involved in regulating endothelial cell differentiation. Receptor activation induces cell–cell adhesion.
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The high resolution crystal structure of the sphingosine 1-phosphate receptor 1 has revealed the architecture of the ligand binding pocket and extracellular region providing insights into the molecular interactions associated with binding and signaling of diverse S1P ligands.

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