sphingomyelin


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Related to sphingomyelin: cerebroside, sphingolipid

sphingomyelin

 [sfing″go-mi´ĕ-lin]
a group of phospholipids that on hydrolysis yield phosphoric acid, choline, sphingosine, and a fatty acid.

sphingomyelin

/sphin·go·my·elin/ (-mi´ĕ-lin) any of the sphingolipids in which the head group is phosphorylated choline; they occur in membranes, primarily in nervous tissue, and accumulate abnormally in Niemann-Pick disease.

sphingomyelin

[sfing′gōmī′əlin]
Etymology: Gk, sphingein + myelos, marrow
any of a group of sphingolipids containing phosphorus. It occurs primarily in the tissue of the nervous system, generally in membranes, and in the lipids in the blood.

Niemann-Pick lipids

A generic term for phospholipids involved in lysosomal storage disease.

sphingomyelin

a group of phospholipids that on hydrolysis yield phosphoric acid, choline, sphingosine and a fatty acid.

sphingomyelin lipidosis
References in periodicals archive ?
Interaction of the nitric oxide signaling system with the sphingomyelin cycle and peroxidation on transmission of toxic signal of tumor necrosis factor-a in ischemia-reperfusion.
Some lipids are produced as a compensatory mechanism and they fulfill a protective role, such as c16-ceramide, PS, sphingomyelin (SM), phosphatidyl ethanolamine (PE), and phosphatidylethanol.
This inhibition results in accumulated sphingosine and sphingamine in serum, urine and tissues, and reduces the biosynthesis of sphingomyelin.
Green DR (2000) Apoptosis and sphingomyelin hydrolysis.
Sphingomyelin of erythrocytes membranes is related to total cholesterol and LDL-Cholesterol in patients with significant coronary arterial disease.
Although designed to bind antigens, the presence of tyrosine and tryptophan allows additional binding possibilities to lipid-rich cell membranes by binding to sphingomyelin [27, 28].
Beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells.
Primarily in conjunction with sphingomyelin, CHOL forms microdomains in which critical exocytotic components are concentrated, including priming factors such as the SNAREs (Lang et al.
Ceramides can be produced by de novo synthesis, sphingomyelin catabolism or on salvage pathway [10].
The result is accumulation of the fatty substance sphingomyelin in the spleen, liver, lungs, bone marrow and, in some patients, the brain.
N-acylsphingosine amidohydrolase 1 (ASAH1, also known as acid ceramidase) is a critical enzyme that catalyzes sphingomyelin synthesis and participates in brain neuronal development and in the metabolism of sphingomyelin.
The sphingomyelin cycle and the second messenger function of ceramide.