spherocytosis


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Related to spherocytosis: thalassemia

spherocytosis

 [sfe″ro-si-to´sis]
the presence of spherocytes in the blood.
hereditary spherocytosis a congenital hereditary form of hemolytic anemia characterized by spherocytosis, abnormal fragility of erythrocytes, jaundice, and splenomegaly.

sphe·ro·cy·to·sis

(sfē'rō-sī-tō'sis),
Presence of spheric red blood cells in the blood.
Synonym(s): microspherocytosis
[spherocyte + G. -osis, condition]

spherocytosis

/sphe·ro·cy·to·sis/ (sfēr″o-si-to´sis) the presence of spherocytes in the blood.
hereditary spherocytosis  a congenital hereditary form of hemolytic anemia characterized by spherocytosis, abnormal fragility of erythrocytes, jaundice, and splenomegaly.

spherocytosis

[sfir′ōsītō′sis]
the abnormal presence of spherocytes in the blood. Compare elliptocytosis.
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Spherocytosis

spherocytosis

Congenital spherocytic anemia, congenital spherocytosis, hereditary spherocytosis, spherocytic anemia Hematology A rare–1:5000 AD condition characterized by chronic hemolytic anemia with ↑ osmotic fragility and autohemolysis of globose RBC due to various defects in RBC membrane proteins Clinical Infants may be jaundiced; other Sx may be seen in older Pts fatigue, weakness, SOB, anemia, intermittent jaundice, splenomegaly, gallstones, leg ulcers Management Splenectomy. Cf Elliptocytosis.

sphe·ro·cy·to·sis

(sfēr'ō-sī-tō'sis)
Presence of spherelike red blood cells in the blood.
[spherocyte + G. -osis, condition]

spherocytosis

A blood disorder in which the red cells are unusually small and spherical. In hereditary spherocytosis the red cells are fragile and burst easily, causing ANAEMIA.

sphe·ro·cy·to·sis

(sfēr'ō-sī-tō'sis)
Presence of spheric red blood cells in blood.
[spherocyte + G. -osis, condition]

spherocytosis

the presence of spherocytes in the blood.
References in periodicals archive ?
High frequency of de novo mutations in ankyrin gene (ANK1) in children with hereditary spherocytosis.
Sharma S, Vukelja SJ, Kadakia S: Gilbert's syndrome coexisting with and masking hereditary spherocytosis.
The results are conflicting regarding the degree of hemolysis, when hereditary spherocytosis and heterozygous [beta] thalassemia coexist.
Treatment for this condition is splenectomy after which spherocytosis persists, but the anemia, if it was present, improves.
In addition, available data, although limited, suggest that sickle cell anemia and hereditary spherocytosis, both disorders in which altered erythrocyte physiology leads to accelerated hemolysis and increased erythropoiesis (which implicates an increased iron demand), also lead to relatively low hepcidin concentrations (176).
Hereditary spherocytosis RBC spectrin RBC ankyrin Hereditary elliptocytosis RBC spectrin Hereditary pyropoikilocytosis RBC spectrin Hemolytic anemia - Glucose- G-6-PD 6-phosphate dehydrogenase deficiency Hereditary nonspherocytic PDH hemolytic anemia - Pyruvate kinase deficiency Porphyrias Various genes encoding enzymes of the heme biosynthesis pathway
65) experimentally showed that PV-B19 significantly inhibited erythroid (CFU-E), myeloid (CFU-myeloid) and megakaryocytic (CFU-Mgk) growth in a patient with hereditary spherocytosis.
In reviewing a slide from a patient with hereditary spherocytosis, participants were advised to go over our policy regarding elevated MCHC results.
6% and peripheral blood smear exhibited polychromasia, spherocytosis, anisocytosis, poikilocytosis, and normoblastemia.
It may be helpful in determining whether impaired glucuronidation contributes to clinical hyperbilirubinemia in subjects with abnormalities in bilirubin metabolism, as in subjects with heterozygous [beta]-thalassemia (17), glucose-6-phosphate dehydrogenase deficiency (18), neonatal icterus associated with glucose-6-phosphate dehydrogenase deficiency (19), or hereditary spherocytosis (20).
Patients with thalassemia major and hereditary spherocytosis were vaccinated at diagnosis with hepatitis B vaccine (3 injections at a dose of 10 [micro]g) if they were seronegative.