2000), we found that echinocytes can be further progressed into spherocytes
(Figure 1A) by prolonged exposure to [Hg.
HS is usually diagnosed clinically from a typical family history and splenomegaly and confirmed by the presence of many spherocytes
and reticulocytes in the peripheral blood film.
Initial blood samples were haemolysed and a blood film revealed marked red cell spherocytes
and occasional nucleated red cell--in keeping with haemolysis.
A peripheral blood smear from the patient had 1 or 2 schistocytes and 1 or 2 spherocytes
per high-power field, a typical platelet morphology, and hyperlobated neutrophils.
Her son revealed very few spherocytes
in peripheral smear and CBC findings were suggestive of [beta]TT.
Interestingly, it has long been held that automated hematocrit results will be one percent to three percent less than the microhematocrit results when abnormal cells such as sickle cells, macrocytes, hypochromic cells, and spherocytes
are present because of the effect of trapped plasma in the micro-centrifuge method.
Peripheral Blood Smear Examination (Under Leishman Stain) Hypochromia Target Cell Microcytosis Polychromasia Anisocytosis Normoblast Poikilocytosis Basophilic Stippling Spherocytes
Section II discusses the specifics of grading individual red blood cell abnormalities and defines a grading system described in words and images for anisocytosis, poikilocytosis, microcytosis, macrocytosis, hypochromia, polychromasia, blister cells, target cells, teardrop cells, schistocytes, sickle cells, spherocytes
, acanthocytes, echinocytes, elliptocytes, stomatocytes, Howell-Jolly bodies, basophilic stippling, Pappenheimer bodies, rouleaux, and agglutination.
However, no spherocytes
or nucleated RBCs were seen in the peripheral smear; rather, a few teardrop cells were present.
The red cell morphology showed anisocytosis, poikilocytosis with occasional teardrop cells, spherocytes
, ovalocytes, and a few schistocytes.
Two populations are evident: large, blue-tinged red cells, which correspond to reticulocytes, and small, dark red spherocytes
Blood smear examination showed marked RBC agglutination, few spherocytes
, neutropenia with an absolute neutrophil count (ANC) of 50/[micro]L, and Wuchereria bancrofti microfilariae (Figure 1a).