level in salt treated plants was much lower than spermine
content in control plants.
Bergeron has recently shown that these structural analogues antagonize the effects of spermidine and spermine
at the NMDA receptor.
supplementation induces intestinal maturation in sea bass (Dicentrarchus labrax) larvae.
Two new quinoline and tris (4-hydroxycinnamoyl) spermine
derivatives from Microdesmis keayana roots.
For example, the first generation of these polyamine analogs, the symmetrically alkylated analogs of either spermidine or spermine
have proved the most successful analogs in depleting intracellular polyamine content and exhibiting a range of therapeutic activities against cancer cells with a selective cell type cytotoxicity (Wallace and Mackarel, 1998).
I will use oligospermines, which are tetramers and octamers of spermine
, an endogenous polyamine, and apply the optimized coupling strategy to target the spermine
based nanocarriers to ATCs for therapeutic GATA-3 knockdown.
The natural polyamine spermine
functions directly as a free radical scavenger.
The most common biogenic amines found in foods are histamine, tyramine, cadaverine, 2-phenylethylamine, spermine
, sperm idi ne, putrescine, tryptamine, and agmatine.
Acrolein can be also generated as a product of endogenous threonine metabol ism (mediated by myeloperoxidase) and/or spermine
metabolism (mediated by amide oxidase) (Esterbauer et al.
(300 [micro]M), used as a positive control, significantly reduces HCEC proliferation (Fig.
Spermidine and spermine
are enriched in whole blood of nona/centenarians.
, an anti-oxidant found in semen that's said to get rid of wrinkles and smoothen out the skin.