spectrin


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spectrin

 [spek´trin]
a contractile protein attached to glycophorin at the cytoplasmic surface of the cell membrane of erythrocytes, important in maintenance of cell shape.

spec·trin

(spek'trin),
A filamentous contractile protein that together with actin and other cytoskeleton proteins forms a network that gives the red blood cell membrane its shape and flexibility; a defect or deficiency of spectrin is associated with hereditary spherocytosis and hereditary elliptocytosis; the principal component of the membrane skeleton of red blood cells. It comprises two units, an alpha unit of MW 280,700 [MIM*182860] and a beta unit of MW 246,040 [MIM*182870].

spectrin

/spec·trin/ (spek´trin) a contractile protein attached to glycophorin at the cytoplasmic surface of the cell membrane of erythrocytes, important in maintaining cell shape.

spectrin

(spĕk′trĭn)
n.
A fibrous protein that links with actin filaments and is the major component of the sturdy cytoskeleton that underlies the plasma membrane of red blood cells.

spec·trin

(spek'trin)
A filamentous contractile protein that together with actin and other cytoskeleton proteins forms a network that gives the red blood cell membrane its shape and flexibility; a defect or deficiency of spectrin is associated with hereditary spherocytosis and hereditary elliptocytosis; the principal component of the membrane skeleton of red blood cells.

spectrin

a contractile protein attached to glycophorin at the cytoplasmic surface of the cell membrane of erythrocytes, considered to be important in the determination of red cell shape.
References in periodicals archive ?
Structural and functional effects of hereditary hemolytic anemia associated point mutations in the alpha spectrin tetramer site.
4-6, 11) The severity of HPP symptoms seen in specific individuals likely relates to the degree of erythrocyte membrane instability conferred by different spectrin mutations.
Dystrophin and beta - Spectrin antibodies were used for immunohistochemistry.
We used b-spectrin (Spec -1 by Novocastra) and dystrophin antibodies because spectrin is localised at the periphery of skeletal muscle fibers like dystrophin and labelling of this protein is thus an excellent control for documenting muscle membrane integrity in the fibers which are negative for dystrophin.
An intrinsic genetic defect causes defects in spectrin, an RBC membrane protein, which are the major components of the cytoskeleton responsible for maintaining the shape of the RBCs.
Frequent de novo moncallelic expression of R-spectrin gene (SPTB) in children with hereditary spherocytosis and isolated spectrin deficiency.
Of the 52 cytoskeleton mRNAs, 30 were similar to actin genes, 12 troponin I, 1 troponin C, 2 tropomyosin, 4 myosin heavy chain, 2 spectrin repeats of muscle specific protein 300, and 1 spectrin repeats of actinin alpha gene).
1989a, b), integrin (Kaminskyj & Heath 1996) and spectrin (Degousee et al.
A conserved region of the MSP-I surface protein of Plasmodium falciparum contains a recognition sequence for erythrocyte spectrin.
Correlation of ischemia/reperfusion and partial outlet obstruction induced spectrin proteolysis by calpain with contractile dysfunction in the rabbit bladder.
Imaging human erythrocyte spectrin with atomic force microscopy.
Furthermore, the brains of alcohol-fed animals had higher levels of the degradation products of a cytoskeletal protein called spectrin, which is degraded by calpains.