spectrin


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spectrin

 [spek´trin]
a contractile protein attached to glycophorin at the cytoplasmic surface of the cell membrane of erythrocytes, important in maintenance of cell shape.

spec·trin

(spek'trin),
A filamentous contractile protein that together with actin and other cytoskeleton proteins forms a network that gives the red blood cell membrane its shape and flexibility; a defect or deficiency of spectrin is associated with hereditary spherocytosis and hereditary elliptocytosis; the principal component of the membrane skeleton of red blood cells. It comprises two units, an alpha unit of MW 280,700 [MIM*182860] and a beta unit of MW 246,040 [MIM*182870].

spectrin

/spec·trin/ (spek´trin) a contractile protein attached to glycophorin at the cytoplasmic surface of the cell membrane of erythrocytes, important in maintaining cell shape.

spectrin

(spĕk′trĭn)
n.
A fibrous protein that links with actin filaments and is the major component of the sturdy cytoskeleton that underlies the plasma membrane of red blood cells.

spec·trin

(spek'trin)
A filamentous contractile protein that together with actin and other cytoskeleton proteins forms a network that gives the red blood cell membrane its shape and flexibility; a defect or deficiency of spectrin is associated with hereditary spherocytosis and hereditary elliptocytosis; the principal component of the membrane skeleton of red blood cells.

spectrin

a contractile protein attached to glycophorin at the cytoplasmic surface of the cell membrane of erythrocytes, considered to be important in the determination of red cell shape.
References in periodicals archive ?
Variable clinical severity of hereditary spherocytosis: relation to erythrocyte spectrin concentration, osmotic fragility and autohemolysis.
Cellular Metabolic Process / putative or Known Genes # of Clones (a) Cytoskeleton mRNAs Actin 30 Tropomyosin (shrimp 2 allergen, involved in actin-binding and muscle contraction) Troponin C 1 Troponin I (similar to 12 Drosophila wupA, has actin-binding activity) Myosin heavy chain-fast 4 Spectrin repeats (c)--Muscle 2 specific protein 300 (actin-binding activity) Spectrin repeats, Actinin 1 alpha (flightless-A, F- actin cross-linking protein) Calcium ion balance (also cytoskeleton mRNAs) Partial homology to putative 3 orthologs of Myosin light chains (MLC1, MLC2, myosin regulatory light chain)--some include EF-hand Cat + binding motif.
7,291,710 "Detection of Spectrin and Spectrin Proteolytic Cleavage Products in Assessing Nerve Cell Damage" and U.
Vital erythroid aggregation takes place with the spectrin ankyrin and actin proteins on the membrane of red blood cells.
Mosior M, Bobrowska M, Gomulkiewicz J (1990a) Effects of the level of ATP and of the state of spectrin on osmotic properties of bovine erythrocytes.
Dystrophin is a plasma membrane-associated cytoskeletal protein of the spectrin superfamily and colocalizes in the membrane skeleton's caveolar domain.
Another possible explanation for hemolysis is the apparent decrease in spectrin content, including deficient or defective spectrin synthesis in thalassemia erythroid precursors or globin chain-induced membrane changes that lead to spectrin dissociation from the membrane [7].
9, Int-1, Lfc, p53-KO: unchanged Krtl-12, mLimk1, MDC2, Mtcp1, Nr2b1, p58 (PKI), Pcnt, PFK, Pkacb, PGII, PTG, beta- spectrin, SPI-3, SNK, TSC-2 C.
5,118,606 relating to the use of spectrin as a marker for degeneration of brain cells.
7,291,710 "Detection of spectrin and spectrin proteolytic cleavage products in assessing nerve cell damage", licensed exclusively by Banyan Biomarkers from the University of Florida.
ATPase, and spectrin antibodies [see Table 2 of the online Data Supplement (available at http://www.