In this study, researchers again used structure-based design to map and re-engineer how spectinomycin
binds to the ribosomes of clinically important bacteria with a focus on generating compounds that work on a broader spectrum of disease-causing bacteria.
The antibiotics spectinomycin
and streptomycin are used extensively in human and animal medicine.
5, 25, 50, and 100 fig/ml), spectinomycin
However, it demonstrated susceptibility to spectinomycin
(16 [micro]/mL) and reduced susceptibility to azithromycin (0.
coli from Humans, Cattle, or Deer were collected, isolated, and tested for growth in the presence of various antibiotics (ampicillin, chloramphenicol, erythromycin, neomycin, oxytetracycline, spectinomycin
dihydrochloride, streptomycin sulfate, and tetracycline hydrochloride) and these results were used to develop discriminant functions that correctly categorized E.
Sequencing analysis indicated a different cassette encoded by the aminoglycoside adenyltransferase aadAl gene conferring resistance to spectinomycin
The distribution of resistance to ampicillin, chloramphenicol, erythromycin, neomycin, oxytetracycline, spectinomycin
, vancomycin, tetracycline, and streptomycin among fecal coliforms was investigated as part of a continuation of an observation of the bacteriological content of Dry Creek in Perry County.
Alternatives include intravenous cefotaxime, 1 g every 8 hours; IV ceftizoxime, 1 g every 8 hours; or IM spectinomycin
, 2 g twice daily Intravenous ciprofloxacin and ofloxacin are good choices for patients allergic to [beta]-lac-tam antibiotics.
Fitness cost due to mutations in the 16S rRNA associated with spectinomycin
resistance in Chlamydia psittaci 6BC.
Standard fastidious anaerobe agar (FAA) supplemented with bovine blood (10%), spectinomycin
(400 [micro]g/mL), and polymyxin B (5 [micro]g/mL) was determined empirically to be the optimal medium for isolation of spirochetes.
These results suggest that 708a may be a natural candidate for genetic manipulation experiments that use gentamicin, spectinomycin
, streptomycin (8), and nourseothricin (9), and validate the use of laboratory-constructed A(amrABoprA) mutants in such experiments.
Susceptibility tests were performed for tetracycline (D and M), erythromycin (D and M), streptomycin (D and M), kanamycin (D), norfloxacin (D), pencillin (D), clindamycin (D), fusidic acid (D), rifampicin (D), cefoxitin (D), ceftiofur (M), chloramphenicol (M), ciprofloxacin (M), florfenicol (M), spectinomycin
(M), sulfamethoxazole (M), tiamulin (M), and trimethoprim (M).