specific pathogen free


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specific pathogen free

a term applied to animals reared for experimentation or to commence new herds or flocks of disease-free animals; abbreviated SPF. Animals usually obtained as for axenic animals but are then placed into a nonsterile environment in which they become infected with a range of microorganisms, many colonizing as so-called normal flora. Certain defined specific pathogenic microorganisms are not present in the environment so that SPF animals can be stated to be free of infection or previous infection with the specified microorganism. See also gnotobiotic animal.
References in periodicals archive ?
To determine the pathogenicity of the isolate, 8 6-week-old specific pathogen free chickens were inoculated intravenously with the virus.
West will describe the Company's gene trap technology for isolating and tracking particular differentiated cell types, the Company's recent published efforts on culturing human stem cells in pathogen-free conditions, unpublished data on the use of specific pathogen free avian systems to culture teratomas, the Company's technologies that are designed to prevent rejection through nuclear transfer and homozygosity in the HLA genes, and lastly, the Company's focus on developing products for dermatological applications in burns and scarless wound repair, applications for retinal disease, blood, and vascular applications.
The expansion in Maine is being driven by growing customer demand for increased specific pathogen free (SPF) polyclonal antibody production.
The animals should be Specific Pathogen Free and should be bred and maintained in accordance with Home Office and EU guidelines.
Rather than using TSV-infected shrimp originated from shrimp farms as a source, TSV infection was induced under laboratory conditions by injecting specific pathogen free (SPF) shrimp (10) Litopenaeus vannamei with purified TSV reference isolate Hawaii-94 (11).
The animals have been cesarean-derived to conform to the specific pathogen free health status characteristic of transgenic mice supplied by GenPharm.