It is at a high level now because of credible evidence that breast cancers express antigens that are recognized by the immune system and that vaccination can boost specific immunity
against these antigens.
Quest has a body of clinical experience and a new appreciation of the obstacles and potential of combinatorial immunotherapeutic approaches to cancer by using either immunoglobulin G or E as immune modulators to enhance tumor specific immunity
and clinical outcome.
Even three years after the last dose of AE37 was administered, elevated levels of specific immunity
could be detected, demonstrating that the vaccine had indeed induced long-term immunological memory.
In addition, the company is advancing a novel therapeutic cancer vaccine aimed to trigger potent and specific immunity
against multiple epithelial cancers, which has the potential to complement its eACT programs.
Understanding the immunological differences between innate and specific immunity
and how those differences manifest in disorders ranging from gluten and other food sensitivities to more sever manifestations, such as celiac disease.