sparteine


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spar·te·ine

(spar'tē-ēn, -tē-in),
An alkaloid obtained from scoparius, Cytisus scoparius and Lupinus luteus; sparteine sulfate was used as an oxytocic drug.
Synonym(s): lupinidine

sparteine

(spär′tē-ēn′, -ĭn)
n.
A bitter, poisonous, liquid alkaloid, C15H26N2, that is present in the broom Cytisus scoparius and in the seeds of several species of Lupinus.

sparteine

a toxic alkaloid found in Spanish broom and lupins. It causes paralysis of sympathetic ganglia and motor nerve endings.
References in periodicals archive ?
Proceedings: N-oxidation of sparteine in man and its interindividual differences.
Phenotyping investigations in whites have consistently shown that 5% to 10% of the population are poor metabolizers with high metabolic ratios for probe drugs such as debrisoquin, sparteine, and dextromethorphan; in Asians only 0% to 1% of populations display poor metabolizing behavior.
Defective N-oxidation of sparteine in man: a new pharmacogenetic defect.
Pharmaco-genetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine.
A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine.
Pharmacokinetics and metabolism of quinidine in extensive and poor metabolizers of sparteine.
Several additional drugs have been identified for use in phenotyping studies, including sparteine and dextromethorphan, and more recently propafenone (Table 3) [16].