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sparteine

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sparteine
a toxic alkaloid found in Spanish broom and lupins. It causes paralysis of sympathetic ganglia and motor nerve endings.
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Commonly used prototype substrate reactions to characterize cytochrome P450 2D6 activity include bufuralol 1'-hydroxylation, debrisoquin 4-hydroxylation, sparteine oxidation, and dextromethorphan O-demethylation.
Cytochrome P450 2D6 polymorphism in white Lebanese population by Saade, Sarita; Mroueh, Mohamad; Saab, Yolande / Journal of Applied Research
At about the same time, an inborn defect of the metabolism of a drug called debrisoquine was found in England[10] and of the drug sparteine in Germany.
Perspectives in Pharmacogenetics by Kalow, Werner / Archives of Pathology & Laboratory Medicine
 
 
 
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