sorbitol pathway

sor·bi·tol path·way

a pathway responsible for d-fructose formation from sorbitol; increases in activity as the glucose concentration rises in diabetes.
Synonym(s): polyol pathway
References in periodicals archive ?
18) In the sorbitol pathway glucose undergoes reduction by NADPH to sorbitol followed by oxidation of sorbitol to fructose in the presence of [NAD.
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism.
Anaerobic glycosis is the centre of different biochemical disarrays associated with the onset of diabetic retinopathy
The consistently elevated blood glucose flows to sorbitol pathway causes increased utilisation of Nicotinamide Adenine Dinucleotide Phosphate-Oxidase (NADPH), which subsequently increases trios-phosphate concentration and thus generates excessive amounts of MG.
Study on the changes of Carbonic Anhydrase activity in insulin resistance and the effect of methylglyoxal
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