Pathologies of the somatotrophic
axis must be excluded in a young patient with an acromegalic phenotype, before considering other differential diagnoses, such as pseudoacromegaly associated with severe insulin resistance or pachydermoperiostosis (3).
The patient underwent transsphenoidal tumor resection; the pathologic diagnosis was pituitary adenoma, granulated somatotrophic type (Figure 2).
After a PubMed and Scopus search, we recovered only three cases of hypertriglyceridemic pancreatitis secondary to somatotrophic pituitary adenoma with elevated lipase and amylase (8).
The recent studies have been indicated that the single nucleotide polymorphisms (SNPs) in relation with genes of the somatotrophic axis are associated with performance traits in dairy cattle.
Changes in the somatotrophic axis associated with the initiation of lactation.
A model of intrauterine growth retardation caused by chronic maternal undernutrition in the rat: effects on the somatotrophic
axis and postnatal growth.
According to their study, a potential mechanism of bone loss in depression involves concurrent activation of the hypothalamic-pituitary-adrenal and sympathoadrenal axes, suppression of the gonadal and somatotrophic
axes, high interleukin-6 and low leptin levels.
Regulation of fetal growth by the somatotrophic
Indeed, a significant correlation was found between plasma concentrations of IGF-1 and the capacity of the high-affinity somatotrophic
binding sites (Breier et al.
The role of the somatotrophic
axis in the metabolism of the chicken.
Among these pathways, the somatotrophic
axis (GH/IGF-I axis) should be emphasized because of its key roles in postnatal growth and metabolism in mammals (Shoshana et al.
2006) were found to enhance the growth performance of weaning pigs and modulate the intestinal microbial population and pH of early-weaned pigs, but the studies on the somatotrophic
axis and immune response were very limited.