GH is synthesized and stored by somatotroph
cells within the anterior pituitary gland.
Patients with dilated cardiomyopathy show reduction of the somatotroph
responsiveness to GHRH both alone and combined with arginine.
In this paper, we reported a male patient who had acromegaly, probably secondary to a pituitary somatotroph
adenoma but now has hypopituitarism with secondary adrenal insufficiency and hypopituitarism.
Proliferation of lactosomatotroph GH3 and somatotroph
MtT/S rat pituitary cells as well as of corticotroph AtT20 mouse pituitary cells was inhibited by curcumin in monolayer cell culture and in colony formation assay in soft agar.
Melamed et al  suggest that estradiol and IGF-I, both generated from cells other than the somatotrophs
, may exert antiapoptotic effects and thus possibly control the size of this somatotroph
However, during aging there is evidence of declining activity of the GH/IGF-I axis, which is mainly dependent on age-related variations in the hypothalamic control of somatotroph
Octreotide acetate is a synthetic somatostatin analogue that binds to somatostatin receptors on somatotroph
tumors and inhibits GH synthesis and secretion.
GH-secreting capability of the pituitary somatotroph
Even variants derived from a single cell type can be distinguished; for example, the subtypes of somatotroph
adenomas are conveniently recognized with the application of keratin stains because sparsely granulated somatotroph
adenomas are characterized by scant GH immunoreactivity and conspicuous fibrous bodies that are stained by the CAM 5.
Ghrelin: a step forward in the understanding of somatotroph
cell function and growth regulation.
Regulation of pituitary somatotroph
differentiation by hormones of peripheral endocrine gland.
In patients with GHD, who have few responsive somatotroph
cells, the conversion factor was also applicable, suggesting that the relative concentration of the 22-kDa form during peak GH responses to the PD-GHRH test remained the same regardless of the number of somatotroph