somatostatin


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Related to somatostatin: Octreotide

somatostatin

 (SRIF, SS) [so″mah-to-stat´in]
a cyclic tetradecapeptide hormone and neurotransmitter that inhibits the release of peptide hormones in many tissues. It is released by the hypothalamus to inhibit the release of growth hormone (GH, somatotropin) and thyroid stimulating hormone (TSH) from the anterior pituitary; it is also released by the delta cells of the islets of Langerhans in the pancreas to inhibit the release of glucagon and insulin and by the similar D cells in the gastrointestinal tract.

so·ma·to·stat·in

(sō'mă-tō-stat'in), [MIM*182450]
A tetradecapeptide capable of inhibiting the release of somatotropin by the anterior lobe of the pituitary gland; somatostatin has a short half-life; it also inhibits the release of insulin, glucagon, and gastrin. Used in the treatment of acromegaly, gigantism, and pancreatic tumors.
[somatotropin + G. stasis, a standing still, + -in]

somatostatin

/so·ma·to·stat·in/ (SS) (-stat´in) a polypeptide elaborated primarily by the median eminence of the hypothalamus and by the delta cells of the islets of Langerhans; it inhibits release of thyrotropin, somatotropin, and corticotropin by the adenohypophysis, of insulin and glucagon by the pancreas, of gastrin by the gastric mucosa, of secretin by the intestinal mucosa, and of renin by the kidney.

somatostatin

(sō-măt′ə-stăt′n, sō′mə-tə-)
n.
A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin.

somatostatin

[sō′matōstat′in]
a hormone produced in the hypothalamus that inhibits the release of somatotropin (growth hormone) from the anterior pituitary gland. It also is produced in other parts of the body and inhibits the release of certain other hormones, including thyrotropin, adrenocorticotropic hormone, glucagon, insulin, and cholecystokinin, and of some enzymes, including pepsin, renin, secretin, and gastrin. Also called growth hormone release inhibiting hormone.

so·ma·to·stat·in

(sō'mă-tō-stat'in)
A tetradecapeptide capable of inhibiting release of somatotropin, insulin, and gastrin.
Compare: bioregulator
Synonym(s): growth hormone-inhibiting hormone, somatotropin release-inhibiting hormone.
[somato- + G. stasis, a standing still, + -in]

somatostatin

a hormone of the hypothalamus that inhibits the release of growth hormone from the pituitary gland.

somatostatin

hormone secreted at several sites, with widespread inhibitory effects on other secretions: from the hypothalamus, as growth hormone-inhibiting hormone (GH-IH) acting in the anterior pituitary; in the pancreas, inhibits other pancreatic secretions; from the intestinal wall, inhibits many hormonal and enzyme secretions in the gut.

so·ma·to·stat·in

(sō'mă-tō-stat'in) [MIM*182450]
Tetradecapeptide capable of inhibiting release of somatotropin by anterior lobe of pituitary gland.
[somatotropin + G. stasis, a standing still, + -in]

somatostatin

a cyclic tetradecapeptide hormone and neurotransmitter that inhibits the release of peptide hormones in many tissues. It is released by the hypothalamus to inhibit the release of growth hormone (GH, somatotropin) and thyroid-stimulating hormone (TSH) from the anterior pituitary; it is also released by the delta cells of the islets of Langerhans in the pancreas to inhibit the release of glucagon and insulin and by the similar D cells in the gastrointestinal tract.
References in periodicals archive ?
McCune-Albright syndrome and acromegaly: effects of hypothalamo-pituitary radiotherapy and/or pegvisomant in somatostatin analog-resistant patients.
Several studies have shown a possible influence of a local decrease in gastric somatostatin (SS) in the physiopathologic characteristic of functional dyspepsia disease.
Internalisation upon ligand exposure is a major characteristic of the G-protein-coupled receptor family and some somatostatin receptor subtypes such as SSTR2a internalise particularly rapidly and efficiently (6).
Vasoactive intestinal polypeptide, somatostatin, and calcitonin-producing adrenal pheochromocytoma associated with the watery diarrhea (WDHH) syndrome: first case report with immunohistochemical findings.
Telotristat etiprate, Lexicon's most advanced product candidate, met the TELESTAR study's primary endpoint with clinically meaningful reductions in bowel movement frequency in cancer patients whose carcinoid syndrome was not adequately controlled by somatostatin analog (SSA) therapy.
com)-- Braasch Biotech LLC, a biopharmaceutical company pioneering a new field of anti-somatostatin vaccines, today announced the company has been notified by China's State Intellectual Property Office (SIPO) concerning the office's approval of a patent application, Compositions and Methods for Enhanced Somatostatin Immunogenicity.
In a multicenter Phase III trial, 151 patients previously managed on injectable somatostatin analogs were switched to the company's investigational octreotide capsules, an oral form of the peptide octreotide, a somatostatin analog, for up to 13 months.
PRRNT is based on the fact that about 70% of these tumours express somatostatin receptors (especially subtype 2) on the cell surface, which constitutes an excellent therapeutic target.
Washington, July 9 ( ANI ): In a new study, researchers have accessed the effectiveness of two somatostatin vaccinations, JH17 and JH18, in reducing weight gain and increasing weight loss in mice.
Topics include the physiological role of vasopressin and oxytocin during the pathophysiology of sepsis, prokineticin 1 and 2, mass spectrometry methods, somatostatin expression during inflammation, and neuropeptide hormone dysregulation in PCOS.

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