somatomedin


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Related to somatomedin: Somatomedin C

somatomedin

 [so″mah-to-me´din]
any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage. Somatomedins also have insulinlike biologic actions and increase RNA synthesis and promote DNA synthesis.

so·ma·to·me·din

(sō'mă-tō-mē'din),
One of several peptides; somatomedin peptide (MW about 4,000), also called insulinlike growth factor II, is synthesized in the liver and probably in the kidney; it is capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein (including chondromucoprotein), and the sulfation of mucopolysaccharides; secretion and biologic activity of somatomedin is known to depend on somatotropin.
See also: insulinlike growth factor.
[somato, tropin + mediator + -in]

somatomedin

/so·ma·to·me·din/ (so″mah-to-me´din) any of a group of peptides found in plasma, complexed with binding proteins; they stimulate cellular growth and replication as second messengers in the somatotropic actions of growth hormone and also have insulin-like activities. Two such peptides have been isolated, insulin-like growth factors I and II.

somatomedin

(sō-măt′ə-mēd′n, sō′mə-tə-)

somatomedin

somatomedin

Any of a group of hormones that mediate the effects of growth hormone (formally, somatopropin):
(1) Insulin-like growth factor-I (somatomedin C);
(2) Insulin-like growth factor-II (somatomedin A);
(3) Vitronectin (somatomedin B).

so·ma·to·me·din

(sō'mă-tō-mē'din)
A peptide synthesized in the liver, and probably also in the kidney, capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein, and the sulfation of mucopolysaccharides; secretion or biologic activity of somatomedin is known to depend on somatotropin.
[somato, tropin + mediator + -in]

so·ma·to·me·din

(sō'mă-tō-mē'din)
One of several peptides; also called insulinlike growth factor II, is synthesized in the liver and probably kidney.
[somato, tropin + mediator + -in]

somatomedin

any of a group of peptides found in the liver and in plasma which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage.

somatomedin C
participates in the limitation of secretion of growth hormone by the pituitary; produced in various tissues, especially liver; called also IGF-1 or insulin-like growth factor.
References in periodicals archive ?
Therefore, our results might most likely reflect the training-induced effect of somatomedin and hormones on cardiac cells.
Evidence from Monoclonal Antibody Studies that Insulin Stimulates DNA Synthesis Through the Type I Somatomedin Receptor," J.
It was designated as <<sulphation factor activity>> (subsequently also termed somatomedin C).
Low levels of somatomedin C in patients with fibromyalgia: A possible link between sleep and muscle pain.
97 mIU/ml (normal); somatomedin C, 315 ng/ml (normal); and cortisol, 19.
Insulin-like growth factor-I (IGF-I), previously known as somatomedin C, has been shown to be essential for normal development and growth in several species.
The hypothesis advanced in Swanson (1990c)--that the anabolic effects of arginine are brought about by systemic or local release of somatomedin C--has also received direct supporting evidence in three recent studies (see Kirk, 1993; Hurson, 1995; Chevalley, 1998); a fourth study by Corpas (1993) reported negative results.
Low levels of somatomedin C in patients with the fibromyalgia syndrome- Arthritis Rheum.
Radioimmunoassay for somatomedin C: comparison with radio-receptor assay in patients with growth-hormone disorders, hypothyroidism, and renal failure.
1987) Serum somatomedin binding proteins: physiologic significance and interference in radioligand assay.