somatomedin

somatomedin /so·ma·to·me·din/ (so″mah-to-me´din) any of a group of peptides found in plasma, complexed with binding proteins; they stimulate cellular growth and replication as second messengers in the somatotropic actions of growth hormone and also have insulin-like activities. Two such peptides have been isolated, insulin-like growth factors I and II.

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so·mat·o·me·din (s-mt-mdn, sm-t-)

n.

A peptide synthesized in the liver, capable of stimulating certain anabolic processes in bone and cartilage, and whose secretion and biological activity are dependent on somatotropin. Also called insulinlike growth factor.

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somatomedin.

See growth hormone.

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somatomedin [so″mah-to-me´din]

any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage. Somatomedins also have insulinlike biologic actions and increase RNA synthesis and promote DNA synthesis.

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somatomedin

any of a group of peptides found in the liver and in plasma which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage.

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somatomedin C

participates in the limitation of secretion of growth hormone by the pituitary; produced in various tissues, especially liver; called also IGF-1 or insulin-like growth factor.