somatic gene therapy


Also found in: Dictionary, Encyclopedia.
Related to somatic gene therapy: somatic cell gene therapy

somatic gene therapy

An experimental method of cloning genes and reintroducing them into cells for the purpose of correcting inherited disease. As this form of therapy develops so do ethical questions concerning its use: what diseases should be treated, and whether an individual could be treated to enhance his or her normal condition (e.g., to become a stronger or faster athlete).
See also: gene therapy

somatic gene therapy

Genetic treatment that affects only the SOMATIC cells and thus is limited in its effect to the individual treated. The alternative form-genetic treatment affecting the germ cells in the ovaries or testicles-may be perpetuated through succeeding generations. For this reason it is generally prohibited.

Somatic gene therapy

The introduction of genes into tissue or cells to treat a genetic related disease in an individual.
Mentioned in: Gene Therapy
Mentioned in ?
References in periodicals archive ?
French Anderson of the University of Southern California, a pioneer of human somatic gene therapy, submitted a proposal to the NIH to begin experiments involving human germline manipulation.
I GENOMIC SEQUENCING Genomic DNA Libraries, Construction and Application Shotgun Sequencing (SGS) Whole Genome Human Chromosome Physical Mapping Serial Analysis of Gene Expression Gene Mapping by Fluorescence in Situ Hybridization Gene Mapping and Chromosome Evolution by Fluorescence-Activated Chromosome Sorting II GENETIC ENGINEERING Gene Targeting Antibody Molecules, Genetic Engineering of Transgenic Fish Transgenic Mice in Biomedical Research Transgenic Plants for Food Use III GENE MEDICINE AND DISEASE Human Genetic Variation and Disease Alzheimer's Disease Triplet Repeat Disease Down Syndrome, Molecular Genetics of Hemophilia, Molecular Genetics of Gene Therapy and Cardiovascular Diseases Somatic Gene Therapy
The present invention further discloses a method for somatic gene therapy, which can be used for various therapeutic applications and involves introducing a gene of interest contained within the retroviral genome into human repopulating stem cells followed by introducing these cells into a human host.
This work represents "a genuine step forward in the slow road to successful somatic gene therapy," comments David Weatherall in an editorial that appears in the same issue.
Few people object to somatic gene therapy, indicates Arthur H.
The research points to the possibility of stimulating genetically defective liver cells to produce normal proteins by using custom-crafted viruses as genetic delivery vehicles --a process known as somatic gene therapy.