smoldering myeloid leukemia

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Subacute myeloid leukemia An indolent myeloma that doesn't evoke significant anemia Clinical Infections, hemorrhage, occasional blast transformation; SML may 'smolder' for 20 yrs, causing osteolysis, hypercalcemia, renal insufficiency DiffDx Smoldering leukemic states–eg, preleukemia, RAEB–refractory anemia with excess blasts, subacute myeloid leukemia; most SMLs arise from a malignant clone, accompanied by refractory cytopenias, cell dysfunction Prognosis Survival ≥ 5 yrs. See Myelodysplastic syndrome, Preleukemia.

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