smoldering


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adult T-cell leukemia-lymphoma

Oncology A rapidly-progressive lymphoproliferative malignancy of mature T lymphocytes, commonly associated with infection by the retrovirus, HTLV-I, first described in southeastern Japan, also seen in the Caribbean, Africa and in blacks in the southeastern US, in whom the disease is aggressive with skin lesions, hypercalcemia, rapid enlargement of hilar, retroperitoneal and peripheral lymph nodes with mediastinal sparing, invasion of CNS, lungs, GI tract, opportunistic infections–eg,.Pneumocystis carinii. See T-cell lymphoma.
Adult T-cell leukemia-lymphoma–clinical forms
Acute
Median age 52, lymphadenopathy, hepatosplenomegaly, cutaneous lesions, up to a 20-year latency, often resistant to chemotherapy with poor prognosis following disease onset Lab ↑ Ca++, WBCs 10-500 × 109–US: 10-500 000/mm3, Sezary-like cells with CD3, CD4, CD2, and Tac+ surface antigens, causing a chronic, smoldering lymphoma
Chronic
Clinically between acute and smoldering disease
Smoldering
Characterized by erythematous skin nodules filled with lymphocytes that may undergo 'blast transformation' to the typical acute T cell leukemia
Crisis
When either 2. or 3. transform to ATL
Lymphoma
Most common in US; affects blacks with hypercalcemia, leukemia, hepatosplenomegaly, erythematous skin lesions, lytic bone lesions

smoldering

Of some cancers or infections, developing, growing, or progressing slowly.
References in periodicals archive ?
Polyurethane foam is resistive to smoldering ignition but ignites easily and will burn vigorously when ignited with an open flame.
cenocepacia, in a patient affected by smoldering myeloma, and chronic hepatitis C virus (HCV) infection.
CPSC Commissioners voted 3-0 last fall to issue an Advance Notice of Proposed Rulemaking (ANPR) to expand the regulatory proceeding on upholstered furniture flammability to include ignitions both by smoldering cigarettes and by small open flames.
Foams with Firemaster 552 have been shown to perform better in the smoldering test (Cal 117 part D) than TDCP foams, particularly at higher densities.
The dryer drum distributes moisture throughout the load by rotating every few seconds, ensuring all laundry is dampened and cooled, and that smoldering pieces are extinguished.
They did note, however, that the Chinese coils emitted significantly less particulate matter, perhaps due to the material used as a smoldering agent (the Chinese products were thought to contain more sawdust, whereas the Malaysian coils were based on coconut husks and shells).
forces found smoldering files in every room and an industrial-strength shredding machine in every other room.
Forest Fire, 2000, which takes full advantage of the medium's capacity to deliver a range of hot lights and smoldering darks, might bring on bad Bambi flashbacks, but it also solicits a shiver of the sublime, and is as good an example of awesome-nature Romanticism as any.
Some survivors no doubt harbor a smoldering grudge against the United States and its citizens.
2] is not effective at extinguishing a smoldering fire, such as buildup in a duct system.
A lack of appropriate community policing and community relations efforts accounted for smoldering, antipolice neighborhoods that erupted into rioting immediately following the 1992 Simi Valley acquittals.
Examples of smoldering business crises would include: