smoldering

(redirected from smolder)
Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.
Related to smolder: smoulder

adult T-cell leukemia-lymphoma

Oncology A rapidly-progressive lymphoproliferative malignancy of mature T lymphocytes, commonly associated with infection by the retrovirus, HTLV-I, first described in southeastern Japan, also seen in the Caribbean, Africa and in blacks in the southeastern US, in whom the disease is aggressive with skin lesions, hypercalcemia, rapid enlargement of hilar, retroperitoneal and peripheral lymph nodes with mediastinal sparing, invasion of CNS, lungs, GI tract, opportunistic infections–eg,.Pneumocystis carinii. See T-cell lymphoma.
Adult T-cell leukemia-lymphoma–clinical forms
Acute
Median age 52, lymphadenopathy, hepatosplenomegaly, cutaneous lesions, up to a 20-year latency, often resistant to chemotherapy with poor prognosis following disease onset Lab ↑ Ca++, WBCs 10-500 × 109–US: 10-500 000/mm3, Sezary-like cells with CD3, CD4, CD2, and Tac+ surface antigens, causing a chronic, smoldering lymphoma
Chronic
Clinically between acute and smoldering disease
Smoldering
Characterized by erythematous skin nodules filled with lymphocytes that may undergo 'blast transformation' to the typical acute T cell leukemia
Crisis
When either 2. or 3. transform to ATL
Lymphoma
Most common in US; affects blacks with hypercalcemia, leukemia, hepatosplenomegaly, erythematous skin lesions, lytic bone lesions

smoldering

Of some cancers or infections, developing, growing, or progressing slowly.
References in periodicals archive ?
The tonalities smolder down into the purple and black that emerge in 7 and 8 so that (except for a few random swabs of red in 9) the last two canvases have the purely graphic and summary quality of black marks on an uninflected white page.
These mosquito coils smolder through the night to keep bugs at bay, but they can also cause asthma and wheezing in children.
Some smolder deep within abandoned mines; others blaze forth in exposed seams of coal.
This similarity suggests that the strain has achieved a stable evolutionary state and can smolder at a low frequency in some populations until unknown factors trigger an outbreak, he says.
A soft smolder, a sassy flounce of red ruffle thrown over the hips, a self-deprecating humor, followed one after the other.