small lymphocytic lymphoma


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lymphoma

 [lim-fo´mah]
any neoplastic disorder of lymphoid tissue, including hodgkin's disease. Often used to denote malignant lymphoma, classifications of which are based on predominant cell type and degree of differentiation; various categories may be subdivided into nodular and diffuse types depending on the predominant pattern of cell arrangement.
adult T-cell lymphoma (adult T-cell leukemia/lymphoma) adult T-cell leukemia/lymphoma.
African lymphoma Burkitt's lymphoma.
B-cell l's a heterogeneous group of lymphoid malignancies including most non-Hodgkin's lymphomas, representing clonal expansions of malignant B lymphocytes that have been arrested at a particular stage in their differentiation from primitive stem cells. B-cell lymphoma usually appears as a painless lymph node enlargement, although extranodal sites of origin are not uncommon. These lymphomas have been classified on the basis of morphologic features characteristic of the different stages of normal B lymphocyte differentiation.
Burkitt's lymphoma see burkitt's lymphoma.
lymphoma cu´tis primary skin involvement by a B-cell lymphoma without demonstrable systemic disease.
diffuse lymphoma malignant lymphoma in which the neoplastic cells infiltrate the entire lymph node without any organized pattern.
follicular lymphoma malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the lymph nodes that somewhat resemble the germinal centers of lymphatic nodules. Follicular lymphomas usually occur in older persons and commonly involve many or all nodes as well as extranodal sites. Called also nodular lymphoma.
follicular center cell lymphoma any of a large group of B-cell lymphomas, comprising four subtypes classified on the basis of the predominant cell type (resembling small cleaved, large cleaved, small noncleaved, and large noncleaved follicular center cells). Because of the wide variety of prognostic levels and the existence of tumors with several types of cells, the original four categories have now been divided up and scattered among several new categories of follicular and diffuse lymphomas.
giant follicular lymphoma follicular lymphoma.
granulomatous lymphoma Hodgkin's disease.
histiocytic lymphoma a rare type of non-Hodgkin's lymphoma of intermediate to high malignancy, characterized by large tumor cells that resemble histiocytes morphologically but are considered to be of lymphoid origin. Many tumors formerly placed in this category are now considered to belong in one of the large cell lymphoma groups.
Hodgkin's lymphoma Hodgkin's disease.
large cell lymphoma any of several types of lymphoma characterized by formation of malignant large lymphocytes in a diffuse pattern; some varieties contain exclusively one type of cell, such as lymphoblasts or cleaved or uncleaved follicular center cells, and others have a mixture of cells, sometimes including ones that cannot be characterized as to lineage.
Lennert's lymphoma a type of non-Hodgkin's lymphoma with a high content of epithelioid histiocytes; bone marrow involvement is common and response to chemotherapy is often poor.
lymphoblastic lymphoma a highly malignant type of non-Hodgkin's lymphoma composed of a diffuse, relatively uniform proliferation of cells with round or convoluted nuclei and scanty cytoplasm, which are cytologically similar to the lymphoblasts seen in acute lymphoblastic leukemia.
malignant lymphoma a group of malignant neoplasms characterized by the proliferation of cells native to the lymphoid tissues, i.e., lymphocytes, histiocytes, and their precursors and derivatives. The group is divided into two major categories: hodgkin's disease and non-Hodgkin's lymphoma.
mixed lymphocytic-histiocytic lymphoma non-Hodgkin's lymphoma characterized by a mixed population of cells, with the smaller cells resembling lymphocytes and the larger ones histiocytes, usually occurring in a nodular histologic pattern but sometimes evolving into a diffuse pattern.
nodular lymphoma follicular lymphoma.
non-Hodgkin's l's a heterogeneous group of malignant lymphomas whose common feature is absence of the giant Reed-Sternberg cells characteristic of hodgkin's disease. They arise from the lymphoid components of the immune system, and present a clinical picture broadly similar to that of Hodgkin's disease except that these diseases are initially more widespread, with the most common manifestation being painless enlargement of one or more peripheral lymph nodes. The nomenclature and classification of these lymphomas has been a subject of controversy. One widely accepted classification is based on two criteria: cytologic characteristics of the constituent cells and type of cell growth pattern (defined as either nodular [follicular] or diffuse). Another system of classification is based on the cell type of origin: T- or B-lymphocytes or histiocytes. Still another formulation has been proposed, separating non-Hodgkin's lymphomas into major histopathologic subtypes using only morphologic criteria.

Diagnostic procedures used to confirm suspected non-Hodgkin's lymphoma include PET scans, gallium scans, and occasionally lymphangiograms. If lymphoma is diagnosed, it will be staged using the same system as for Hodgkin's disease.

Treatment will depend on the type and stage. It may be single agent or multiagent chemotherapy, radiation therapy, biotherapy, or a combination. Blood transfusions and bone marrow transplantation have shown efficacy for some types of lymphoma.

Patient care: major problems presented by the patient with non-Hodgkin's lymphoma include the management of side effects associated with treatment and the prevention of infection.
small lymphocytic lymphoma a diffuse form of non-Hodgkin's lymphoma with a low grade of malignancy; it represents the neoplastic proliferation of well-differentiated B lymphocytes and may present with either focal lymph node enlargement or generalized lymphadenopathy and splenomegaly. The predominant cell type is a compact, small, normal-appearing lymphocyte with a dark-staining round nucleus, scanty cytoplasm, and little size variation. It nearly always involves the bone marrow, and often malignant cells are found in the blood, so that its clinical picture is similar to that of chronic lymphocytic leukemia. Called also well-differentiated lymphocytic lymphoma.
T-cell l's a heterogeneous group of lymphoid tumors representing malignant transformation of the T lymphocytes. Types include convoluted T-cell lymphomas, cutaneous T-cell lymphomas, adult T-cell leukemia, and certain other conditions.
undifferentiated lymphoma malignant lymphoma composed of undifferentiated cells, i.e., cells that do not show morphologic evidence of maturation toward lymphocytes or histiocytes, which vary in size and may include bizarre giant forms.
well-differentiated lymphocytic lymphoma small lymphocytic lymphoma.

small lymphocytic lymphoma

a type of low-grade non-Hodgkin lymphoma characterized by enlarged lymph nodes and other lymphoid tissue or bone marrow that are infiltrated by small lymphocytes. May be associated with features of chronic lymphocytic leukemia such as lymphocytosis, lymphadenopathy, and, in late stages, hepatosplenomegaly, anemia, and thrombocytopenia. Histology is identical between these two disease entities; it consists of predominantly small lymphocytes with condensed chromatin and round nuclei. Larger lymphocytes (prolymphocytes and paraimmunoblasts) with more prominent nucleoli and dispersed chromatin are always present, usually in clusters. Characteristic immunophenotype of these cells is CD5 and CD23 positivity, in addition to B-cell associated antigens CD19 and CD20. CD23 positivity is useful to distinguish this disease from mantle cell lymphoma, which does not express the antigen.

small lymphocytic lymphoma

Well differentiated lymphoma Oncology A type of NHL involving mature appearing B-cells, more common in elderly Pts Location Spreads in lymph nodes later involving spleen, liver, BM Subtypes Lymphoplasmacytic lymphoma, B-cell chronic lymphocytic leukemia, B-cell prolymphocytic leukemia; SLL is closely linked to CLL. See Chronic lymphocytic leukemia, Lymphoma, WHO classification.

small lymph·o·cyt·ic lym·pho·ma

(smawl lim-fō-sitik lim-fōmă)
Low-grade non-Hodgkin lymphoma characterized by enlarged lymph nodes and other lymphoid tissue or bone marrow that are infiltrated by small lymphocytes.
References in periodicals archive ?
Follicular lymphoma, small lymphocytic lymphoma, and mantle cell lymphoma are the most common systemic B-cell lineage lymphomas to secondarily involve the lung.
director of the Leukemia/Lymphoma Program at the University of Michigan Comprehensive Cancer Center, on 14 small lymphocytic lymphoma (SLL) patients treated with Bexxar in four Phase I-III clinical trials.
Specific NHL diagnoses included are: small lymphocytic lymphoma or follicular lymphoma (small cleaved, mixed or large cell) as classified by the International Working Formulation Classification; or small lymphocytic, lymphoplasmacytoid, marginal, or follicular lymphoma as categorized by the Revised European-American Lymphoma (REAL) classification of the International Lymphoma Study Group (ILSG).
Among cases of small lymphocytic lymphoma, a slightly brighter intensity of 4E-BP1 expression was noted within the proliferation centers in comparison with the surrounding small mature lymphocytes.
Germinal centers in 10 reactive lymphoid tissue Mantle/marginal zones in 10 reactive lymphoid tissue Follicular lymphoma 12 Small lymphocytic lymphoma 9 Mantle cell lymphoma 7 Extranodal marginal 5 zone lymphoma Diffuse large 13 B-cell lymphoma Burkitt lymphoma 4 Intensity of 4E-BP1 Expression, No.
Responses by specific cancer subtype ranged from 67% ORR in patients with small lymphocytic lymphoma, 60% ORR in patients with follicular lymphoma, and 60% ORR in patients with mantle cell lymphoma.
The Phase II study will enroll up to 60 patients over the age of 65 with CLL or small lymphocytic lymphoma (SLL).
To describe the key features and provide diagnostic clues to the identification of specific extranodal low-grade lymphomas of T-cell and B-cell types including small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, extranodal marginal zone B-cell lymphomas of mucosal-associated lymphoid tissue, and hairy cell leukemia.
Small lymphocytic lymphoma involving an enlarging complex renal cyst.
In a single-arm, dose-escalation study, 35 patients have been enrolled with various subtypes of NHL, including diffuse large B-cell, follicular, mantle cell, marginal zone and small lymphocytic lymphomas (abstract 695).

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