small airways disease


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small airways disease

 
chronic obstructive bronchitis with irreversible narrowing of the bronchioles and small bronchi. See also obstructive small airways disease.

small airways disease

A condition in which airway obstruction is attributed to ↓ luminal dimension; SAD is largely confined to the small airways or bronchioles–< 2 mm in diameter, initiated by inhaled irritants and is most common in smokers; it is accompanied by inflammation, hypersecretion, and small airway changes, including fibrosis, ulceration, metaplasia, smooth muscle proliferation. Cf COPD.
References in periodicals archive ?
Although etiologies are numerous, small airways disease may be generally divided into small airways disease related to tobacco; to various other exposures, including mineral dusts; to diseases involving other areas of the lung, with secondary bronchiolar involvement; and to idiopathic causes.
Miller doesn't expect 100% concordance with his results, but believes the DOD-funded research will validate Vanderbilt's findings of small airways disease.
COPD is a slowly developing progressive small airways disease comprised broadly of chronic bronchitis and emphysema, and characterized by airflow limitation and decreased lung function.
For example, the FEF25-75% helps distinguish healthy smokers from healthy nonsmokers in large groups of individuals; this suggests it could be an early marker of small airways disease.
Small airways disease, subdivided into mineral dust-associated small airways disease (11) and smoking-related small airways disease (12,13), was identified, and exposure to cigarette smoke in the recent past was assessed on the basis of accumulation of characteristic smokers' macrophages within the respiratory bronchioles and adjacent alveoli (14,15).

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