ARF3

(redirected from small GTP-binding protein)

ARF3

A gene on chromosome 12q13 that encodes a protein of the ADP-ribosylation factor gene family, which encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and are involved in vesicular trafficking as phospholipase D activators.
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12/13]-type G proteins, which leads to activation of small GTP-binding proteins Rho through activation of RhoGEF (RhoGTPase nucleotide exchange factor) (see a review ref.
Small GTP-binding proteins (G-proteins) of the Rho family have been shown to regulate cytoskeleton reorganization, whereas G-proteins of the Rab family have been shown to regulate intracellular trafficking and vesicle transport (1).
Despite the dramatic changes induced by EPEC in the cytoskeleton, there appears to be little involvement of the Rho family of small GTP-binding proteins normally involved in cytoskeletal rearrangements (29).
coli belong to a group of bacterial toxins that modify Rho, a subfamily of small GTP-binding proteins that are regulators of the actin cytoskeleton (28,29).
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