To advance the science of sleep architecture
in normal and disordered sleep, at FORENAP we have developed a unique technology platform that includes electroencephalography and imaging techniques to monitor sleeping and awake subjects," said Remy Luthringer, PhD, head of the FORENAP Institute for Research in Neurosciences and Neuropsychiatry in Rouffach, France, an international contract research organization (CRO) specialized in drug development and neurosciences research.
However, no significant differences in physiologic arousal or sleep architecture
were found between testing conditions.
Although changes in sleep architecture
are to be expected with increasing age, age itself does not result in disturbed sleep.
For example, the few studies that have been done regarding sleep in ventilated patients demonstrate that unconscious hours are plentiful but sleep architecture
is badly disrupted.
In a Phase 2a trial, when compared to placebo, patients treated with APD125 achieved statistically significant improvements in objective measurements of sleep maintenance, or the ability to maintain sleep during the night after falling asleep, and sleep architecture
There are several age-related changes in sleep architecture
These improvements in clinically accepted measures of obstructive sleep apnea severity were not associated with a change in sleep architecture
that has been reported for other candidate pharmacotherapies previously investigated for the treatment of sleep apnea.
Polysomnographic findings often reveal normal sleep architecture
and characteristic REM-associated abnormalities (increase in chin EMG activity, and excess REM-associated limb activity)16.
Sleep fragmentation, sleep architecture
and sleep duration were similar for all three ventilator modes as the difference between the modes for the 15 subjects were not statistically different.
The PSG analysis also showed that EVT 201 did not have a negative impact on sleep architecture
unlike many benzodiazepine full agonists.
These results suggest that the effect of MCH-1 receptor antagonism on caloric regulation and sleep architecture
requires further study in humans.
Review on SDB in elderly discusses age-related changes in sleep architecture
, aetiology, presentation, and treatment of sleep disorders among the elderly and other factors relevant to aging that are likely to affect sleep quality and quantity (18).