sleep apnoea syndrome

sleep apnoea syndrome

A condition clinically defined by frequent episodes of sleep apnoea, hypopnoea and symptoms of functional respiratory impairment. Sleep apnoea syndrome is potentially life-threatening, and has been associated with daytime hypersomnolence, motor vehicle accidents) and cardiovascular disease (hypertension, stroke, arrhythmias and myocardial infarction); it is more common in the obese and in heavy snorers. 2% of middle-aged females and 4% of males meet the criteria for sleep apnoea syndrome.
 
Pathogenesis
Marked alveolar hypoventilation during sleep (despite normal blood-gas levels while awake) due to a failure of autonomic ventilation, resulting in sleep apnoea, arrhythmias and hypertension. Sleep apnoea primarily affects the severely obese (due to tonsillar hyperplasia, relative micrognathia and central apnoea, with loss of the ventilatory drive in the medulla), but may follow bilateral cervical cordotomy used to control intense midline or perineal cancer-related pain (by severing the spinothalamic tract through a ventrolateral incision into the second cervical segment), or may rarely occur in infants; primary hypoventilation is secondary to a loss of CNS chemoreceptor response, which affects men aged 20 to 60.
References in periodicals archive ?
Liver enzymes in obstructive sleep apnoea syndrome.
More daytime sleepiness was also linked with slower thinking while sleep apnoea syndrome was linked with poorer attention and thinking speed.
Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization.
He had failed to tell Dr Lesley Anne Somerville at his licence medical that he'd had high blood pressure readings, and denied that he had sleep apnoea syndrome.
Validation of the modified Berlin questionnaire to identify patients at risk for the obstructive sleep apnoea syndrome.
Non-arteritic anterior ischaemic optic neuropathy and presumed sleep apnoea syndrome screened by the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ).
Objective: Polysomnography (PSG) remains the gold standard for the diagnosis of obstructive sleep apnoea syndrome (OSAS).
The prevalence of obstructive sleep apnoea syndrome in ankylosing spondylitis patients.
Objectives: To elucidate the variations of the lateral pharyngeal wall anatomy on physical examination and to assess the clinical importance of the examination of the lateral pharyngeal wall on the presence and severity of obstructive sleep apnoea syndrome.
Booth had submitted that he might have fallen asleep due to obstructive sleep apnoea syndrome, rather than tiredness, in the run-up to the crash.