sleep apnoea syndrome

sleep apnoea syndrome

A condition clinically defined by frequent episodes of sleep apnoea, hypopnoea and symptoms of functional respiratory impairment. Sleep apnoea syndrome is potentially life-threatening, and has been associated with daytime hypersomnolence, motor vehicle accidents) and cardiovascular disease (hypertension, stroke, arrhythmias and myocardial infarction); it is more common in the obese and in heavy snorers. 2% of middle-aged females and 4% of males meet the criteria for sleep apnoea syndrome.
 
Pathogenesis
Marked alveolar hypoventilation during sleep (despite normal blood-gas levels while awake) due to a failure of autonomic ventilation, resulting in sleep apnoea, arrhythmias and hypertension. Sleep apnoea primarily affects the severely obese (due to tonsillar hyperplasia, relative micrognathia and central apnoea, with loss of the ventilatory drive in the medulla), but may follow bilateral cervical cordotomy used to control intense midline or perineal cancer-related pain (by severing the spinothalamic tract through a ventrolateral incision into the second cervical segment), or may rarely occur in infants; primary hypoventilation is secondary to a loss of CNS chemoreceptor response, which affects men aged 20 to 60.
References in periodicals archive ?
Booth had submitted that he might have fallen asleep due to obstructive sleep apnoea syndrome, rather than tiredness, in the run-up to the crash.
Untreated patients with obstructive sleep apnoea syndrome are at between four and seven times greater risk of having road traffic accidents, especially serious ones, than the rest of the population.
Furthermore, a chapter on obstructive sleep apnoea syndrome, one of the most common sleep disorders, is included.
Influence of subclinical hypothyroidism and T4 treatment on the prevalence and severity of obstructive sleep apnoea syndrome (OSAS).
2] Meslier N, Gagnadoux F, Giraud P, Person C, Ouksel H, Urban T, Racineux JL: Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome.
Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study.
The study, published in the online British Medical Journal, looked at obstructive sleep apnoea syndrome and snoring.
Automobile Accidents in Patients with Sleep Apnoea Syndrome.
The patients have sleep apnoea syndrome, a breathing difficulty which disrupts sufferers' sleep causing them to feel drowsy during the daytime.
They can also develop sleep apnoea syndrome which means they can stop breathing for up to 30 seconds.