In males, both skeletal and dental fluorosis was more common, and the prevalence of skeletal fluorosis
increased with age.
The reported economic consequences  to persons affected by skeletal fluorosis
should also be of concern.
in humans: a review of recent progress in the understanding of the disease.
can be defined as excessive deposition of fluoride in bone (Saraux et al.
Excess of fluoride causes dental, skeletal and non skeletal fluorosis
through continued use of fluoride contaminated water, air and agriculture produce .
Fluorosis, a condition caused by an excessive in-take of fluoride, manifests itself in the form of dental or skeletal fluorosis
, when it attacks teeth or bone respec-tively.
Given the patient's history of well-water and instant-tea consumption, radiographic findings, and increased plasma fluoride, the diagnosis of skeletal fluorosis
Excess fluoride intake has been reported to produce dental and skeletal fluorosis
in animals affecting teeth and bones during development.
The York review analysed 25 studies with a wide variety of outcomes, including Alzheimer's disease, impaired mental functioning, dementia, cognitive impairment, Down's syndrome, congenital malformations, mortality, infant mortality, IQ/mental retardation, anaemia during pregnancy, age at menarche, Sudden Infant Death syndrome, skeletal fluorosis
, dental fluorosis, endocrine changes, neurological effects, and even death may occur with chronic overdose or acute poisoning.
Still, it would take about 10 milligrams of fluoride a day for 10 years to lead to the rare condition called skeletal fluorosis
that this woman experienced.
Endemic skeletal fluorosis
in children: hypocalcemia and the presence of renal resistance to parathyroid hormone.