sirtuins


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Related to sirtuins: resveratrol

sirtuins

Enzymes that appear to be important in the biochemical processes that relate calorie intake restriction to vitality and longevity. See also RESVERATROL.
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Resveratrol, a compound found in red wine, mimics calorie restriction by activating the sirtuins and extending the healthy lifespan of animals.
Second, NAD+ activates (3) key anti-aging enzymes called sirtuins.
Her current work contributes to the understanding of how mitochondrial sirtuins regulate tumor cell metabolism.
David Sinclair (professor of genetics at the Harvard Medical School, USA), the scientific community is starting to understand the role of longevity genes - sirtuins - in prolonging life expectancy.
Mounting evidence has demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries, increases the activity of a specific sirtuin, SIRT1, that protects the body from diseases by revving up the mitochondria, a kind of cellular battery that slowly runs down as we age.
In the present study, they found that sirtuins boost metabolism by promoting the browning of white fat.
Some anti-ageing creams contain a chemical to activate sirtuin, a protein linked to longer life.
So that is one thing sirtuins do; they keep the spool wound tight.
Sirtuins are associated with increasing lifespan (for a review see [1]).
Other topics include sirtuins in biology and disease, epigenetics and its genetic syndromes, epigenetics and immunity, epigenetics and cardiovascular disease, plant epigenetics, and epigenomics.
But Sassone-Corsi and his colleagues suspected that sirtuins might be involved because the proteins respond to a cell's energy state by plucking acetyl groups from histones and other proteins.
The activation of sirtuins helps reduce weight gain, as well improve glucose levels and insulin sensitivity.