SIRT4

(redirected from sirtuin 4)

SIRT4

A gene on chromosome 12q24.31 that encodes an NAD-dependent protein ADP-ribosyl transferase that catalyses the transfer of ADP-ribosyl groups onto target proteins (e.g., mitochondrial GLUD1), inhibiting its enzyme activity. SIRT4 interacts with GLUD1, IDE and SLC25A5, is widely expressed, especially in vascular smooth muscle, striated muscle and in beta-cells in pancreas islets; it downregulates insulin secretion.