SIRT1

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SIRT1

A gene on chromosome 10q21.3 that encodes a widely expressed NAD-dependent protein deacetylase, which links transcriptional regulation to intracellular energetics and co-ordinates distinct cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. SIRT1 can modulate chromatin function by deacetylating histones and altering the methylation of histones and DNA, leading to transcriptional repression. It deacetylates a broad range of transcription factors and co-regulators, up- and downregulating target gene expression.
References in periodicals archive ?
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3.
Proteins known as sirtuins are necessary to achieve this life span extension, with sirtuin 1, or SIRT1, often regarded as the most important.
28 ( ANI ): A new study has found that activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice.
A team of scientists at the National Institutes of Health in US conducted experiments on mice models and found that a protein called sirtuin 1 (SIRT1) played a major role in ageing process.
Experiments on cultivated mouse cells in the laboratory confirmed that metformin has a direct effect on the vascular function through interaction with a protein called sirtuin 1, which is encoded by the SIRT1 gene, known to play a role in ageing.
The Sirtuin 1 (class III) enzyme represents a target for treatment of age-related diseases and type II diabetes.
The authors presented evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging.
Cue stomach rumbles Sirtuin 1 sets clock to Metabolism
BIOMOL tests show that RevGenetics herbal resveratrol in its X1000 capsule has the ability to activate the Sirtuin 1 gene and was at times better than research-grade resveratrol.
Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.
MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1," Oncology Reports, vol.