SIRT1

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SIRT1

A gene on chromosome 10q21.3 that encodes a widely expressed NAD-dependent protein deacetylase, which links transcriptional regulation to intracellular energetics and co-ordinates distinct cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. SIRT1 can modulate chromatin function by deacetylating histones and altering the methylation of histones and DNA, leading to transcriptional repression. It deacetylates a broad range of transcription factors and co-regulators, up- and downregulating target gene expression.
References in periodicals archive ?
Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism.
Proteins known as sirtuins are necessary to achieve this life span extension, with sirtuin 1, or SIRT1, often regarded as the most important.
28 ( ANI ): A new study has found that activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice.
A team of scientists at the National Institutes of Health in US conducted experiments on mice models and found that a protein called sirtuin 1 (SIRT1) played a major role in ageing process.
The Sirtuin 1 (class III) enzyme represents a target for treatment of age-related diseases and type II diabetes.
The authors presented evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging.
Cue stomach rumbles Sirtuin 1 sets clock to Metabolism
June 7 /PRNewswire/ -- An independent laboratory test confirms that Longevinex(TM), a red wine dietary supplement, exhibits significant biological activity, potently activating the Sirtuin 1 gene, known as a survival factor in living cells.
BIOMOL tests show that RevGenetics herbal resveratrol in its X1000 capsule has the ability to activate the Sirtuin 1 gene and was at times better than research-grade resveratrol.
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
3 Cell, researchers report that resveratrol does not activate sirtuin 1 directly.
Sirtuin 1 (SIRT1), the human homolog of yeast Sir2 (Silent Information Regulator 2), is the most studied of the seven members of sirtuin family.