sirtuin


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sirtuin

(sûr′to͞o-ĭn, -tyo͞o-)
n.
Any of a family of enzymes that occur in all living organisms and are thought to regulate cellular aging, apoptosis, and resistance to stress in more complex eukaryotic organisms.
Any of a class of proteins that possess either histone deacetylase—more commonly—or mono-ribosyltransferase activity, named after Sir2, the cell-regulating yeast gene silent mating-type information regulation 2. Sirtuins regulate critical biological pathways in eubacteria, archaea and eukaryotes.
Sirtuins influence ageing, transcription, apoptosis, stress resistance, and affect energy efficiency and alertness during hypoglycaemia
Most sirtuins are protein deacetylases in which sirtuin-mediated deacetylation couples lysine deacetylation to NAD hydrolysis—instead of simple hydrolysis of acetyl-lysine residues—yielding O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide. The dependence of sirtuins on NAD links their enzymatic activity directly to the energy status of the cell via the cellular NAD:NADH ratio, the absolute levels of NAD, NADH or nicotinamide or a combination of these variables.

sirtuin

(sĭr′too-ĭn)
Any of a class of proteins that are coded by the SIR family of genes. These proteins contribute to chromosome repair and may have a role in extending the life span of cells.
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Unfortunately, you have to drink too much red wine to get enough of the ingredient to activate your sirtuin gene.
Those proteins, called sirtuins, are a group of enzymes found in organisms from bacteria to humans, which have been shown to regulate aging in yeast, roundworms and fruit flies.
EX-527 stands as one of the most potent SIRT1 inhibitors reported to date and also shows high selectivity for SIRT1 compared to other sirtuin deacetylases and over 50 other receptors, enzymes, transporters and ion channels.
Regulation of sirtuin function by posttranslational modifications.
For the last decade, the science of aging has increasingly focused on sirtuins, a group of genes that are believed to protect many organisms, including mammals, against diseases of aging.
For this reason, the search is on for a substance that stimulates sirtuin in the body to harness its lifespan-boosting and anti-aging benefits.
According to William LaMarr, Vice President of Research and Contract Services at BIOCIUS, "validation using a label‐free, functional assay is especially important for sirtuins given the controversy surrounding fluorescent based assays recently seen in the scientific literature.
Summary: TEHRAN (FNA)- A new paper from MIT biology professor Leonard Guarente strengthened the link between longevity proteins called sirtuins and the lifespan-extending effects of calorie restriction.
We expect this transaction will accelerate our vision to target sirtuins to treat diseases of metabolism and ageing and deliver tremendous value to patients, our shareholders and our employees.
Using these models, researchers have discovered that sirtuin proteins (proteins that can silence genes) have the ability to extend life span in yeast.
Sirtuin 1 (SIRT1), the human homolog of yeast Sir2 (Silent Information Regulator 2), is the most studied of the seven members of sirtuin family.