sinus histiocytosis with massive lymphadenopathy

si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

a chronic disease occurring in children and characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.

sinus histiocytosis with massive lymphadenopathy

Rosai-Dorfman disease

A rare, benign idiopathic condition characterised by bilateral cervical lymphadenopathy. It is most common in young black men and women, but may affect other ages and races; it may be extranodal. 

Clinical findings
Massive bilateral cervical lymphadenopathy, fever.

Lab
Leukocytosis, increased erythrocyte sedimentation rate, polyclonal hyperimmunoglobulinaemia.
 
Prognosis
Uncertain; most resolve spontaneously, but some are aggressive and ultimately fatal.

sinus histiocytosis with massive lymphadenopathy

Rosai-Dorfman disease Hematology condition most common in young blacks Clinical Massive bilateral cervical lymphadenopathy, fever, leukocytosis, ↑ ESR, polyclonal hyperimmunoglobulinemia Prognosis Uncertain; most resolve spontaneously; some are aggressive and ultimately fatal. Cf Sinus histiocytosis.

si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

(sī'nŭs his'tē-ō-sī-tō'sis mas'iv limf-ad-ĕ-nop'ă-thē)
A chronic disease occurring in children characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.
Synonym(s): Rosai-Dorfman disease.

Rosai,

Juan, U.S. pathologist, 1941–.
Rosai-Dorfman disease - Synonym(s): sinus histiocytosis with massive lymphadenopathy
References in periodicals archive ?
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity.
Immunological abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy.
Sinus histiocytosis with massive lymphadenopathy has remained a disorder of unknown etiology, and no characteristic cytogenetic or molecular abnormalities have been documented in the literature.
Multifocal, extranodal sinus histiocytosis with massive lymphadenopathy.
Immunologic abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy.
The treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).
Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of the head and neck.
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case with widespread nodal and extra nodal dissemination.
Sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndrome.
The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy.
Practically, the most common problem in differential diagnosis in cases of lymph node involvement is to distinguish sinus histiocytosis with massive lymphadenopathy from so-called sinus hyperplasia (sinus histiocytosis), a nonspecific reaction to a wide variety of agents, although, theoretically, many diseases can resemble Rosai-Dorfman disease morphologically.
Fine needle aspiration cytology and immunohistochemical characterization of the histiocytes in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman Syndrome).