single nucleotide polymorphisms


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sin·gle nu·cle·o·tide pol·y·mor·phisms

(sing'gĕl nū'klē-ō-tīd pol'ē-mōrph'izmz)
Variation between two DNA sequences consisting in the difference of a single nucleotide, frequently the substitution of thymine for cytosine. Although the possession of a pair of alleles displaying such polymorphism seldom causes demonstrable abnormality or malfunction, it may influence the response to pathogens, toxins, and environmental agents and enhance susceptibility to certain conditions.
References in periodicals archive ?
A map of human genome sequence variation containing 1,42 million single nucleotide polymorphisms.
Largescale identification, mapping, and genotyping of single nucleotide polymorphisms in the human genome.
Princeton, NJ; 609-750-2200) announced that they have entered into an agreement to develop and commercialize single nucleotide polymorphism genotyping assays that combine Orchid's proprietary GBA primer extension technology with a new GeneChip array product offering from Affymetrix.
was formed between leading academic centers and pharmaceutical companies to discover genetic variations, particularly single nucleotide polymorphisms, and to make those discoveries publicly available.
The CodeLink Bioarray platform includes ready-to-use microarrays of mouse, rat, and human genes for gene expression profiling as well as a ready-to-use microarray of single nucleotide polymorphisms (SNPs).
Products for multiplex profiling of single nucleotide polymorphisms (SNPs), transcription factors and phosphoproteins are in development and are slated for launch next year.
The CodeLink Human P450 SNP Bioarray genotypes 110 single nucleotide polymorphisms (SNPs) within nine P450 genes (CYP1A1, 1A2, 1B1, 2C9, 2C19, 2D6, 2E, 3A4, and 3A5) offering comprehensive coverage of the P450 drug metabolism genes for research applications in genotyping and pharmacogenomic profiling.
At the heart of a system is an electrochemical DNA chip that is able to analyze and type single nucleotide polymorphisms (SNPs), common DNA sequence variations that can be used to identify genes.
Hakonarson and his colleagues will first conduct whole-genome genotyping using Sentrix(R) HumanHap550 BeadChips, each of which can analyze over 550,000 single nucleotide polymorphism (SNP) loci with industry-leading per-sample genomic coverage and data quality.
The BeadStation 500GX is an integrated system that supports single nucleotide polymorphism (SNP) genotyping and RNA profiling applications on a single platform.

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