single nucleotide polymorphism


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polymorphism

 [pol″e-mor´fizm]
the ability to exist in several different forms.
balanced polymorphism an equilibrium mixture of homozygotes and heterozygotes maintained by natural selection against both homozygotes.
genetic polymorphism the occurrence together in the same population of two or more genetically determined phenotypes in such proportions that the rarest of them cannot be maintained merely by recurrent mutation.
single nucleotide polymorphism (SNP) a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.

single nucleotide polymorphism (SNP),

the naturally occurring substitution of a single nucleotide at a given location in the genome of an organism, the more interesting of which results in phenotypic variability, including alterations in the organism's physiologic responses to endogenous hormones and neurotransmitters or endogenous substances.

single nucleotide polymorphism (SNP)

a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.

single nucleotide polymorphism (SNP, ‘snip’)

a single BASE PAIR position in genomic DNA where different sequence alternatives exist for normal individuals in the population. Differences between individual genomes are largely due to SNPs. Over 1.4 million SNPs have been identified in the human GENOME. SNPs in coding regions of the genome are designated cSNPs; those in regulatory regions, rSNPs; and those in JUNK DNA regions, anonymous SNPs. SNPs generate variability, particularly where they occur in coding regions, thereby contributing to the biological characteristics of an individual. For example SNPs reflect differences in susceptibility to, and protection from, a range of diseases. An SNP can be detected by OLIGONUCLEOTIDE HYBRIDIZATION, using for example DNA CHIPS.
References in periodicals archive ?
The single nucleotide polymorphism (SNP) genotyping market development trends and marketing channels are analyzed.
We expect GeneChip arrays to play an increasing role in the genotyping market and look forward to applying our technologies to high-volume, flexible single nucleotide polymorphism detection products.
GEN ID is preparing to unveil, to the medical community, its proprietary software, which specializes in the expedited analysis of Single Nucleotide Polymorphism (SNP) cells.
The method is especially amenable to the analysis of large numbers of sequences, such as single nucleotide polymorphisms, from one sample of nucleic acid.
A new interactive web site called MitoAnalyzer has been developed by NIST researchers that allows users to determine the effects of single nucleotide polymorphisms, mutations, insertions, or deletions in human mitochondrial DNA.
The most troublesome version of the gene contains three specific variations, or single nucleotide polymorphisms (SNPs), within its DNA sequence.
Identifying Single Nucleotide Polymorphisms and the EGP
1) discussed the frequency of single nucleotide polymorphisms (SNPs) in two genomes of Mycobacterium tuberculosis, strains H37Rv (2) and CDC1551 (unpublished).
The determination of single nucleotide polymorphisms (SNPs) and their phase (for haplotypes) also requires contiguity of varying length.
Central to the assay is a new GeneChip HuSNP probe array, containing oligonucleotides of known sequence enabling simultaneous interrogation of nearly 1500 single nucleotide polymorphisms covering all 22 autosomes and the X chromosome in a single experiment.

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