simian virus 40

Also found in: Dictionary, Acronyms.
Related to simian virus 40: adenovirus

sim·i·an vac·u·o·lat·ing vi·rus No. 40 (SV40),

a small (40-45 nm) DNA virus of the genus Polyomavirus, family Papovaviridae; the cause of seemingly inapparent infections in monkeys, especially rhesus, and a common contaminant of monkey cell cultures; the virus may cause inapparent infection in humans and may be excreted in stools of children for several weeks; it can produce fibrosarcoma in suckling hamsters, and transformation may occur in human diploid cells; it may also form "hybrid" virus in cells also infected with certain adenoviruses.
Synonym(s): simian virus 40

simian virus 40 (SV40)

a vacuolating virus isolated from the kidney tissue of rhesus monkeys. SV40 produces malignancy in human and newborn hamster kidney cells and tumors when inoculated into newborn hamsters.
References in periodicals archive ?
Association of Simian Virus 40 (SV40) With Animal and Human Malignant Mesothelioma Evidence Strength of Evidence Experimental Strong Molecular Moderate but controversial Epidemiologic Moderate but controversial
Serological cross-reactivities between antibodies to simian virus 40, BK virus, JC virus assessed by virus-like-particle-based enzyme immunoassays.
Differential ability of two simian virus 40 strains to induce malignancies in weanling hamsters.
Comparison of three rhesus groups for antibody patterns to some viruses: absence of active simian virus 40 transmission in the free-ranging rhesus of Cayo Santiago.
Neutralizing antibodies to simian virus 40 (SV40) in human sera from India.
There are huge information gaps in data used by the government to come up with the conclusion that simian virus 40 (SV40) contaminating early polio vaccines have not played a role in human cancers.
In every construct, the tag sequence included codes for the 11-aa KPPTPPPEPET epitope of simian virus 40 (SV40) large T-antigen (31,32).
After antigen retrieval with ethylenediaminetetraacetic acid at pH 8 and microwaving at 900 W (2 steps of 3 minutes, followed by 2 steps of 4 minutes), immunoperoxidase staining was performed using a polyclonal antibody against the VP1 through VP3 proteins of simian virus 40 (dilution, 1:20000; Lee Biomolecular Research Labs, San Diego, Calif), which cross-reacts with human BKV and JCV.
A virologist colleague had shown Twarock a 1991 scientific article that reported that every one of the 72 capsomers of a polyoma-type virus called Simian Virus 40 (SV-40) is a pentamer.
The UROtsa cell line was derived from the normal urothelium lining the ureter and was immortalized using the simian virus 40 (SV40) large T antigen (17,18).