silibinin


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silibinin

One of two major constituents of silymarin (silibinins A and B), the main extract of milk thistle (Silybum marianum seeds), which have hepatoprotective effects (e.g., against Amanita phalloides (deathcap mushroom) poisoning) and anti-cancer activity (in animal models) against prostate adenocarcinoma, breast carcinoma cells, cervical carcinoma cells, colon cancer and both small and non-small lung carcinomas. It may also be useful for cirrhosis and type-2 diabetes.
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Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells.
5-3% silymarin (approximately 50% silibinin(= silybin)) (Figure 3), silichristin, silidianin, silimonin, isosilichristin, isosilibinin, silandrin (Figure 4), silhermin, neosilihermins A and B, 2,3-dehydrosilibinin and tritopentamers of silibinin (silybinomers).
Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.
We show that silibinin does both," said Rajesh Agarwal, co-programme leader of Cancer Prevention and Control at the Colorado University Cancer Centre.
He took omeprazole for his reflux and had taken the sparfloxacin and silibinin given to him while in India.
Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy, and her team found that treatment with silibinin stopped the spread of these lung cancers in mouse.
Numerous novel HCV specific inhibitors such as nucleoside and non nucleoside polymerase inhibitors, protease inhibitors, as well as non HCV specific compounds with antiviral activity such as nitazoxanide, cyclophilin inhibitors (Debio 025), silibinin are under development in clinical trials.
Antidotes to [alpha]-amanitin include silibinin (extract of milk thistle) and intravenous benzyl penicillin, thought to decrease the hepatocellular uptake of the toxin.
The use of high dose silibinin combined with phosphatidylcholine should not be used during chemotherapy to prevent therapeutic outcomes being compromised.
Silibinin (Legalon-Sil[R]) amatoksinin hepatositlerce tutulmasini engeller.
Penicillin G and silibinin are accepted antidotes, despite the lack of data on their use from controlled trials.