signet-ring cell carcinoma

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sig·net-·ring cell car·ci·no·ma

a poorly differentiated adenocarcinoma composed of cells with a cytoplasmic droplet of mucus that compresses the nucleus to one side along the cell membrane; arises most frequently in the stomach, occasionally in the large bowel or elsewhere.
References in periodicals archive ?
The final diagnosis was a colloid signet-ring cell carcinoma of the colon with lymph node involvement.
The extreme rarity of a primary colorectal signet-ring cell carcinoma metastatic to the tonsil reflects the fact that this particular histologic type of cancer occurs in only about 1% of all cases of colorectal carcinoma.
However, a PAS or PAS-D stain is not specific for the establishment of signet-ring cell carcinoma because some signet-ring cell melanomas may show PAS+ intracellular inclusions (Table).
Primary signet-ring cell carcinoma of the uterine cervix with long term follow-up: case report.
3,4] Saphir first described primary signet-ring cell carcinoma of the bladder in 1955, and less than 200 cases have been reported in the literature since then.
The only histologic types of colorectal carcinoma that have been shown to have adverse prognostic significance independent of stage are signet-ring cell carcinoma (6) and small cell carcinoma (high-grade neuroendocrine carcinoma).
4,5) High-grade tumors, such as signet-ring cell carcinomas, small cell carcinomas, and undifferentiated carcinomas, are associated with a poorer prognosis compared with adenocarcinoma.