Cytologic criteria were Nuclear morphology (Large nuclei, Anisonucleosis, Hyperchromatic nuclei, Vesicular nuclei, Chromatin clumping, Prominent nucleoli, Multiple nucleoli), and Cellular morphology (Comet cells, Signet ring cells
, Vacuolar cytoplasm, Granular cytoplasm, Apocrine cells, Ractive ductal cells, Squamous cells).
The prostatic lymphomas with infiltrated lymphocytes containing a large cytoplasmic vacuole and an eccentric nucleus may also resemble signet ring cells
An ultrasound-guided fine needle aspirate yielded only a small sample containing atypical signet ring cells
, which were not diagnostic but suspicious for malignancy.
The signet ring cells
within these tumors can demonstrate a plasmacytoid or monocytoid appearance or can have the classic signet ring cell
morphology, characterized by a large cytoplasmic vacuole compressing the nucleus to one side of the cell.
Myxoid liposarcomas are as common as the welldifferentiated type; they are composed of proliferating lipoblasts at varying stages of differentiation, signet ring cells
, a plexiform capillary pattern, and a myxoid matrix with nonsulfated glycosaminoglycans.
The tumor was composed of well-formed glands containing abundant mucin and signet ring cells
The tumor was composed of signet ring cells
within a desmoplastic stroma, displaying an Indian file pattern of infiltration (Fig.
Hematoxilin and eosin staining of these biopsies displayed islands of adenocarcinoma with signet ring cells
surrounded by a desmoplastic reaction (Fig.
Lumina may mimic signet ring cells
, but mucin staining will differentiate between the two.
12] SRCs are composed of signet ring cells
, displaying large mucin containing intracellular vacuoles; signet ring cells
are morphologically similar to UC lipoid cells.
Degenerative change with extracellular mucin is acceptable Adenocarcinoma ex GCC, Goblet cells or signet ring cells
signet-ring-cell type arranged in irregular large clusters (group B) and sheets Single cell-infiltrating pattern Significant cytologic atypia Reduced intracellular mucin Marked desmoplasia Destruction of appendiceal wall Adenocarcinoma ex GCC, Requires at least focal evidence poorly differentiated of goblet cell morphology A (group C) component (>1 low-power field or 1 [mm.
Small tubules with blue mucin lined by a single cell and resembling signet ring cells
may be seen (Figure 1, C).