According to Woodruff and Novak, Krukenberg's original criteria for this eponymous tumor were (i) tumor in the ovary, (ii) signet ring cells
indicating intracellular mucin production, and (iii) sarcoma-like infiltration into the ovarian stroma.
Microscopically, the tumours showed diffuse infiltration by signet ring cells
with surrounding zones of desmoplasia.
Signet ring cells
are more frequently seen focally within otherwise high-grade prostate cancers and should be considered as part of the Gleason scoring.
Signet ring cells
and increased mitosis were also seen.
Origin of Sample Histology 1 Lymph Adenocarcinoma, node solid 2 Primary Adenocarcinoma tumor with signet ring cells
3 Lymph Adenocarcinoma, solid node 4 Primary Adenocarcinoma tumor with signet ring cells
5 Brain Adenocarcinoma metastasis with signet ring cells
6 Primary Adenocarcinoma tumor with signet ring cells
7 Primary Adenocarcinoma, solid tumor 8 Lymph Adenocarcinoma, solid node 9 Lymph Adenocarcinoma node with signet ring cells
10 Pleural Adenocarcinoma metastasis 11 Primary Adenocarcinoma tumor Case No.
Cytologic criteria were Nuclear morphology (Large nuclei, Anisonucleosis, Hyperchromatic nuclei, Vesicular nuclei, Chromatin clumping, Prominent nucleoli, Multiple nucleoli), and Cellular morphology (Comet cells, Signet ring cells
, Vacuolar cytoplasm, Granular cytoplasm, Apocrine cells, Ractive ductal cells, Squamous cells).
Mucinous and signet ring cells
were more often identified (p=0.
Myxoid liposarcomas are as common as the welldifferentiated type; they are composed of proliferating lipoblasts at varying stages of differentiation, signet ring cells
, a plexiform capillary pattern, and a myxoid matrix with nonsulfated glycosaminoglycans.
The tumor was composed of well-formed glands containing abundant mucin and signet ring cells
Figure 8: Metastatic Signet ring cell
carcinoma: HPE shows normal ovarian follicular lining with abundant signet ring cells
infiltrating the stroma.
172) Other malignant tumors should be considered if signet ring cells
are present: (1) poorly differentiated adenocarcinoma with focal signet ring cells
; (2) squamous cell carcinoma with signet ring-like cells; (3) clear cell carcinoma with signet ring cells
; and (4) metastatic signet-ring cell carcinoma (more often gastrointestinal and breast origin).