signal transduction inhibitor

sig·nal trans·duc·tion in·hib·i·tor

(STI) (sig'năl trans-dŭk'shŭn in-hib'i-tŏr)
Category or classification of anticancer drugs that inhibit the action of enzymes essential to the growth and survival of cancer cells while causing relatively little or no damage to noncancer cells.
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The lead signal transduction inhibitor compound, perifosine, is an orally-active AKT inhibitor that is in several Phase II trials for multiple cancers.
Researchers say Glivec, developed by Novartis Oncology, acts as a signal transduction inhibitor, a new class of drugs that can interfere with cell signaling pathways implicated in tumor development.
Session Name -- Lymphoma: Pre-Clinical Chemotherapy and Biologic Agents -- Novel Agents, including Small Molecule Inhibitors Mechanistic paradigm for combination signal transduction inhibitor therapy in Zap70+ CLL involves bicompartmental functions of EZH2 Monday, December 10, 2007 5:00 p.
Procyon's presentation titled: "PCK3145: A Novel signal transduction inhibitor for treating late stage prostate cancer," will take place at 1:00 P.
The lead signal transduction inhibitor compound, perifosine, is a novel, first-in-class, oral anticancer agent that modulates several key signal transduction pathways, including AKT, MAPK, and JNK that have been shown to be critical for the survival of cancer cells.
Furthermore, our lead signal transduction inhibitor in cancer, perifosine, yielded positive Phase II results in 25 patients suffering from hormone-sensitive prostate cancer.
The integrative model for the mechanism of action suggests PCK3145 to be a signal transduction inhibitor with multiple ways (apoptosis, anti-angiogenesis and anti-metastasis) to restrict disease development.
We believe the angiogenesis and signal transduction inhibitor classes will provide the greatest revenue potential, congruent with their combined clinical and commercial appeal.
There is a significant shift away from cytotoxic agents, with the current pipeline dominated by cancer immunotherapies and signal transduction inhibitors - - What is the scientific rationale behind these mechanisms of action?
The chemopreventive activity of these agents and other novel signal transduction inhibitors are discussed in this chapter.
In this collection of 11 articles, contributors describe their work in PTKs in such areas as using PTKs as targets for cancer and other indications, targeting Src homology 2 domains in drug discovery, using P12-kinase inhibition as a target for therapeutic intervention, using an activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia and JAK kinases in leukemia, lymphomas and multiple myeloma, applying platelet-derived growth factor, using a targeted therapy for myelogenous leukemia, testing signal transduction inhibitors in animal models of cancer, and using phosphoproteomics in drug discovery and development.
Signal transduction inhibitors, a new class of cancer drugs targeting solid tumors without the toxic side effects of chemotherapy, are causing treatment-resistant folliculitis in up to 75% of patients.

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