signal transduction


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signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
References in periodicals archive ?
REASONS FOR DOING THIS STUDY Significant developments have come about in both the understanding of the complexity of signal transduction pathways such as JAK and PI3K over the past couple of years.
In the preceding section we described advances in our understanding of signal transduction and the idea that nonmammalian systems could be used as models to evaluate the effect of test agents on key signaling pathways.
Chapter- 4: REGULATORY ASPECTS RUXOLITINIB (INC424) TOFACITINIB (CP-690,550) REGULATORY DEVELOPMENTS OF SIGNAL TRANSDUCTION THERAPIES/INHIBITORS/BIOMARKERS Chapter- 5: NEW DEVELOPMENTS NEW DEVELOPMENTS COLLABORATIVE TRIALS AND FUTURE ACTIVITIES Chapter- 6: MARKET ANALYSIS-SIGNAL TRANSDUCTION THERAPIES (JAK AND PI3K)
AxCell's growing signal transduction technology platform, such as its proprietary ProChart database, Genetic Diversity Library(tm), Cloning of Ligand Targets(tm), and affinity screening technologies are specifically designed to shorten the drug discovery process by allowing researchers to define the best point for intervention in a protein pathway to maximize beneficial pharmacological effects while minimizing potential toxicity.
Cellular stimulation can lead to activation of different signal transduction mechanisms, such as alterations of the cytoplasmatic levels of different ions.
It may be used as a companion for a course on regulation and signal transduction as well as an introductory reference to the field for students and researchers.
Signal transduction describes cellular response to external or internal stimuli and often results in fundamental cellular changes such as regulating gene expression or controlling cell proliferation.
AntexBiologics (Gaithersburg, MD; 301-590-0129) announced that the United States Patent and Trademark Office has allowed another patent on Antex's Helicobacter pylori vaccine produced using the company's Nutriment Signal Transduction platform technology.
While at Eli Lilly, he spearheaded initiatives that incorporated state-of-the-art proteomics platforms for quantitative analysis of signal transduction pathways, including innovative mass spectrometry approaches.
Researchers in neurobiology, immunology, and related specialties provide a theoretical and practical foundation for scientists at any level who are interested in studying their role in signal transduction at the cellular level.
The Company's broad 20 product pipeline leverages six different therapeutic approaches, including LHRH antagonists and signal transduction inhibitors.

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