STAT5B

(redirected from signal transducer and activator of transcription 5B)

STAT5B

A gene on chromosome 17q11.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT5B protein product is activated by and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones.

Molecular pathology
In a subset of acute promyelocytic leukaemias, STAT5B fuses to RARA (retinoic acid receptor-alpha), resulting in signalling pathway dysregulation that may cause APLL.
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