signal sequence


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Related to signal sequence: Signal recognition particle, Transmembrane domain

leader peptide

or

signal sequence

a PEPTIDE of about 15 to 30 AMINO ACIDS at the N-terminus of certain newly synthesized PROTEINS. The peptide can mediate transport of such a protein across the ENDOPLASMIC RETICULUM or CELL MEMBRANE. It is afterwards cleaved from the protein. Leader peptides can be exploited in GENE CLONING in order to export foreign proteins to the exterior of HOST cells.

signal sequence

see signal sequence.
References in periodicals archive ?
Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage in vitro is lethal for virus production.
Genes which encode secreted proteins are characterized by the presence of a specific sequence -- known as the signal sequence -- located at the 5 prime end of the coding region.
RCT manages commercialization of the bgh-polyA signal sequence for Case Western Reserve University in Cleveland, which assigned RCT the rights to its U.
No change in the signal sequence was noted for CIN0309R, the only isolate sequenced completely in this region.
patented signal sequence trap (SST) technology, a rapid method to