sickling crisis

sickling crisis

An acute episode in homozygous sickle cell disease in which a massive breakdown of red blood cells occurs with widespread severe pain from blockage of small blood vessels by sickled red cells. Some cases involve great enlargement of the liver or spleen and gross anaemia, others may affect the lungs with severe breathlessness and pleuritic pain, or the brain causing a stroke. Skilled and energetic management in hospital is mandatory for the sickling crisis.
References in periodicals archive ?
Herein, we report a case involving the coexistence of beta thalassemia minor, renal amyloidosis and FMF with the E148Q heterozygous mutation in a 46-year-old male patient with sickle cell anemia (SCA) whose abdominal pains had been attributed to sickling crisis for almost 25 years.
In conclusion, when physicians encounter patients with sickling crisis, they should consider a concurrent diagnosis of FMF, Particularly for patients living on the Mediterranean coast, recurrent abdominal pain and fever should be assessed since these symptoms are frequently associated with FMF in this region.
The sickling crisis in SCT women may occur in cases of extreme anaemia, dehydration, acidosis, vigorous exertion and at high altitude.
Preoperative exchange transfusion may be a safe alternate protocol to prevent a sickling crisis on bypass.
This can lead to these small blood vessels getting blocked which then stops the oxygen from getting through to where it is needed, a process known as sickling crisis.
Hypoxia, lack of oxygen in the blood, is associated with the initiation of cell sickling and severe cell sickling crisis.