sickling


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sickling

 [sik´ling]
the development of sickle cells in the blood.
sickling test a method of demonstrationg hemoglobin S and the sickling phenomenon in erythrocytes, performed by reducing the oxygen concentration to which the erythrocytes are exposed.

sick·ling

(sik'ling),
Production of sickle-shaped erythrocytes in the circulation, as in sickle cell anemia.

sickling

/sick·ling/ (sik´ling) the development of sickle cells in the blood.

sickling

the development of sickle-shaped red blood cells, as in sickle cell anemia.

sick·ling

(sik'ling)
Production of sickle-shaped erythrocytes in the circulation, as in sickle cell anemia.

sickling

the development of sickle cells in the blood.

Patient discussion about sickling

Q. Please precribe for me the possible medicine (treatment) for sickle cells. Secondly, my boy lost hearing at 4 1- I need to know how sickle cells can be treated. 2- My boy just surprisingly lost his abillity to hear anything at the age of 4.

A. wow...you are going through some hard times...it's the hardest thing in the world seeing your children in pain. loosing his hearing could be caused by clots that were formed and destroyed the ear nerve. but it's unlikely it happened in both ears...so i would check it out. and about treatment- there are a variety of treatments, so i found a web site with them all. and even some that are still in research: http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_Treatments.html

More discussions about sickling
References in periodicals archive ?
Lastly, the authors state that our article advocated interpreting a negative sickling test as the patient being negative for the disease, with no further testing required.
Transfusion of packed red blood cells temporarily replaces a portion of the defective cells and decreases sickling Muff, 1989).
Perioperative exchange transfusion depends on general condition of patient and type of surgical procedure, it does wonders to reduce the circulating HbS concentration, minimize sickling and prevent SCD-specific complications.
I have been tested for Sickling and I know my phenotype.
In the 1970s, physicians noticed that some adult Saudi Arabian and Indian patients with sickle cell anemia developed only mild symptoms because they had somehow continued to make high amounts of fetal hemoglobin, which prevented their red blood cells from sickling.
Such transfusions would help prevent stroke by substituting normal blood cells for the sickling cells, Pavlakis says.
A laboratory animal with sickle cell disease could offer new insights into the mechanisms of red-blood-cell sickling and serve as an ideal subject for experimental drugs.
This mutation causes the formation of sickle-shaped red blood cells, which are less deformable, more fragile and susceptible to hemolysis, leading to anemia and episodic vaso-occlusive crises and pain when sickling occurs and tissues are deprived of oxygen.
But shortly after birth, the body's hemoglobin-making system switches to produce adult hemoglobin, which will cause sickling in people with the disease.
Weiner envisions that this process, in addition to modifying the blood of patients with ischemic disease, could help transfusion patients with sickle cell disease, because their painful sickling occurs only when affected blood cells give up their oxygen.
The company has also shown, in two separate in vitro studies, that CPC-111 reduces the red blood cell sickling that causes the blood-starvation-induced tissue damage in sickle cell crisis.
In pre-clinical studies, CPC-111 has been shown to prevent this sickling process.