sickle-cell trait


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sickle-cell trait

heterozygous expression of haemoglobin S (HbS) gene (i.e. individual carries both HbS [sickle haemoglobin] and HbA [normal] genes, but does not express characteristics of sickle-cell anaemia); HbS-containing erythrocytes tend to deform (sickle) when tissue oxygen tension is low (e.g. when tourniquet is applied); see anaemia, sickle-cell
References in periodicals archive ?
In the Sergipe maroon community under analysis, three cases of individuals with sickle-cell trait were reported (Table 1).
In Generation III, the sickle-cell trait gene was probably transmitted by the male individual, father of P3 and P4, who is not a permanent resident in the maroon community under study anymore, having divorced the spouse (Figure 1) and began a new marital relationship.
The African Americans and the Caucasian race were reported in 93% and 7% of the valuable cases, respectively; whereas the sickle-cell trait was found in 97.
The sickle-cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigens.
The test to determine whether a person is G-6-PD deficient, like the sickle-cell trait test, has racial and ethnic repercussions because G-6-PD deficiency occurs in approximately 12 percent of black males and in 12 percent of persons of Mediterranean origin.
Disparate treatment is present when a screening procedure is used to treat people of protected groups differently; for example, if a company screens for sickle-cell trait in blacks only.
Those with an abnormal gene from only one parent, however, have sickle-cell trait, ordinarily considered an innocuous disorder.
The authors suggest that although civilian life is "seldom as stressful as basic military training,' studies should be done on sickle-cell trait among others involved in strenuous exercise, such as athletes and heavy laborers.
The University has admitted that they learned about Plancher's sickle-cell trait during physical exams that Plancher and other football players underwent in January 2007, Dowell said.
Of the three traits, HbS in the heterozygous form, sickle-cell trait (HbAS), has been studied most.
In a study conducted in Gabonese children with asymptomatic malaria (73), there was a significantly lower prevalence of infection in children with sickle-cell trait compared to their normal-haemoglobin counterparts.
Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle-cell trait.