sialyltransferase


Also found in: Wikipedia.

sialyltransferase

(1) N-acetyllactosaminide alpha-2,3-sialyltransferase, EC 2.4.99.6.  
(2) (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-d-galactosaminide alpha-2,6-sialyltransferase, EC 2.4.99.7. 
(3) Neolactotetraosylceramide alpha-2,3-sialyltransferase, EC 2.4.99.10.
References in periodicals archive ?
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells.
The equivalent gene in serogroups W and Y is also a sialyltransferase, but it also has a glycosyltransferase function and is distinct from the serogroups B and C genes.
After injury, regenerating hepatocytes have increased sialyltransferase activity and synthesize hypersialylated proteins (e.
Thus CHO cell lines appear to express the [alpha]2,3-sialyltransferase but not a functional [alpha]2,6 sialyltransferase (27).
Similarly, increases in the expression of both FucT-IV and the sialyltransferase ST3Gal II are observed in human colorectal cancer biopsy specimens compared with adjacent noncancerous tissue (54).
Enhanced sialyltransferase activity in B lymphocytes from patients with primary Sjogren's syndrome.
Alteration of terminal sialylation is suggested to be the result of decreased activity of sialyltransferase in the Golgi.
To explore the etiology of this finding, measurements of neuraminidase and sialyltransferase activity (9) and of the sialyltransferase mRNA concentration (10) may be useful.
This confirms the impaired sialylation of Tf induced by alcohol abuse, which probably is attributable to the alteration of glycosyltransferases, particularly sialyltransferase (33-35).
For the second assay, we developed a novel glycosylation immunosorbent assay (GISA), based on the specificity of sialyltransferase and immunosorbent technology.
TagMan probes specific for the meningococcal capsular transfer gene (ctrA), insertion seq IS1106, and the sialyltransferase gene (siaD) were designed for serogroup B and C determination.
3]H-labeled leucine and N-acetyl-d-mannosamine into Tf, lower [alpha]2,6-sialyltransferase mRNA concentrations (because of destabilization by ethanol), decreased synthesis of [alpha]2,6-sialyltransferase, which is followed by lower sialyltransferase activity, and decreased sialylation of Tf in rats chronically fed alcohol were observed by Lakshman et al.