Mucous membrane cells, such as those that line the internal airways of the lungs, nose and throat, defend themselves against such pathogens by secreting a mucus rich in sialic acids
- a gooey trap intended to bog down viral particles before they can infect vulnerable cells.
Sialix' Scientific Advisory Board will help to guide and advise the company as it continues research efforts focused on the development of products to treat and prevent diseases associated with the ingestion of non-human sialic acid
(Neu5Gc) found in red meat and other dietary sources.
Lysosomal sialidase (neuroaminidase) cleans sialic acid
residues located in the last part of gangliosides, oligosaccharides and glycoproteins.
To discard a polymorphic variant of Tf, selected samples were digested with neuraminidase from Clostridium perfringens to remove the negatively charged terminal sialic acid
Varki's group and one in Japan subsequently found that, the human genome harbors only an inactive version of the gene that in chimps encodes an enzyme for the sialic acid
In addition, encapsulation, measured by mean production of sialic acid
, was reduced in the LH/HC expressing the HH covR/S locus by 29% compared with the parent LH/HC strain (from 24 to 17 fmol N-acetylneuraminic acid/103 CFU).
Diabetes mellitus is associated with an increase in sialic acid
concentration along with other complications.
Earlier, majority of scientists concluded that some viruses depend on sialic acid
to infect the body, while others were thought to cause infection independent of sialic acid
The current strains still prefer [alpha]-2,3-1inked sialic acids
, which is typical of avian influenza viruses, whereas human influenza viruses bind preferentially to [alpha]-2,6-1inked sialic acids
Until now, most sialic acid
-specific lectins have been purified from invertebrates, and only a few plant-derived lectins that specifically bind to sialic acids
have been studied as potential antifungal agents (Takashi and Ajit, 2002).
Two mechanisms may explain the observed serum impairment: degradation of Tf molecules (attributable to endogenous enzymes and/or bacterial contamination), leading to a decrease in total Tf, and fixation of free sialic acids
[naturally present in blood in considerable amounts (18)] on Tf isoforms having N-glycans but without terminal sialic acid
, causing dominance of forms with a higher number of fixed sialic acid
1F), which removes the terminal sialic acids
of the N-glycans (19, 20).