susceptibility cassette

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susceptibility cassette

a common sequence of amino acids in residues 70-74 in the HLA-DRB1 chains, found in alleles associated with rheumatoid arthritis. It is one of two variations: glutamine[Q]-lysine[K]-arginine[R]-alanine[A]-alanine[A] or QRRAA. These susceptibility cassettes are found in many different DRB1 alleles. The α and β chains that form these antigen-presenting molecules have a configuration not unlike a trough or rain gutter; antigens are bound by sequences of amino acids in a pocket along the bottom and sides of the trough or cavity, and this complex forms a heterotrimer with the T-cell receptor on CD4+ cells.

sus·cep·ti·bil·i·ty cas·sette

(sŭ-sep'ti-bil'i-tē kă-set')
A common sequence of amino acids in residues 70-74 in the HLA-DRB1 chains, found in alleles associated with rheumatoid arthritis. It is one of two variations: glutamine[Q]-lysine[K]-arginine[R]-alanine[A]-alanine[A] or QRRAA; found in many different DRB1 alleles. The alpha and beta chains that form these antigen-presenting molecules have a configuration not unlike a trough or rain gutter; antigens are bound by sequences of amino acids in a pocket along the bottom and sides of the trough or cavity, and this complex forms a heterotrimer with the T-cell receptor on CD4+ cells.
Synonym(s): rheumatoid pocket, shared epitope.
References in periodicals archive ?
The HLA-DRB1 shared epitope in Caucasians with rheumatoid arthritis: a lesson learned from tic-tac-toe.
Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA) positive rheumatoid arthritis in three asian ethnic groups.
Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles.
A case-control study in Denmark between 2002 and 2004 found that subjects who were shared epitope carriers and smoked, drank more than five cups of coffee each day, or used oral contraceptives were at high risk for anti-CCP-positive RA.
From the clinicians point of view, it is beneficial to outline briefly the current clinical practice to better understand the diagnostic performance and predictive value of RF, ACPAs, and HLA class 11 shared epitope for the diagnosis of RA, as discussed by Hoffman et al.
This is in contrast to findings by other investigators who have recently reported that the presence of anti-CCP antibodies together with shared epitope (SE) gene carriage is associated with a very high relative risk for future development of RA (4).
More recently, a nationwide case-control study conducted in Denmark between 2002 and 2004 found that subjects who were shared epitope carriers and smoked, drank more than five cups of coffee each day, or used oral contraceptives were at high risk for anti-CCP-positive RA.
Furthermore, the HLA shared epitope (SE) has been described, which is found more often in RA patients than in controls (16-18).
The presence of HLA alleles containing the shared epitope was not predictive of the disease course in the long run, Dr.
The presence of the HLA-DRB1 gene--which is also known as the shared epitope and, until recently, was considered the most important genetic factor in RA--conferred only a twofold increased relative risk of future RA in the Swedish population, the physician observed at the congress, which was sponsored by the European League Against Rheumatism (EULAR).
If the test antibody shared epitope specificity with the ISOBM workshop reference antibody, the labeled reference antibody would be unable to bind and no signal would be generated.
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