sex hormone-binding globulin


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sex hor·mone-bind·ing glob·u·lin (SHBG),

a plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in certain types of liver disease and in hyperthyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.

sex hor·mone-bind·ing glob·u·lin

(SHBG) (seks hōrmōn-bīnding globyū-lin)
Plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men.
Synonym(s): testosterone-estrogen-binding globulin.

sex hormone-binding globulin

A plasma glycoprotein that binds androgens or estrogens, leaving small concentrations of free hormones to circulate in the blood.
See also: globulin
References in periodicals archive ?
The effects of postmenopausal hormone therapy on serum estrogen, progesterone, and sex hormone-binding globulin levels in healthy postmenopausal women.
Association of sex hormone-binding globulin and insulin resistance among Japanese-American subjects.
Synthesis and regulation of sex hormone-binding globulin in obesity.
BACKGROUND: Human sex hormone-binding globulin (SHBG) regulates free sex steroid concentrations in plasma and modulates rapid, membrane based steroid signaling.
Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome.
We used the Delphia system for the assay of sex hormone-binding globulin (SHBG) in serum; materials were obtained from Wallac, Inc.
Serum levels of free/total testosterone and sex hormone-binding globulin were assessed.
Neither drug produced significant reductions in fasting insulin, insulin resistance, sex hormone-binding globulin, or any of several lipid parameters studied.
The investigators assessed circulating testosterone levels using liquid chromatography tandem mass spectrometry, which has a sensitivity of about 2 ng/dL, and measured sex hormone-binding globulin (SHBG) through immunoflourometric assay.
It has been proposed, but not experimentally demonstrated, that the concentration of testosterone not tightly bound to sex hormone-binding globulin (SHBG) [7] could be considered the "bioavailable" fraction of circulating testosterone (12).
Her study measured baseline total testosterone, free testosterone, and sex hormone-binding globulin (SHBG) in premenopausal women (mean age 34) who had been using hormonal contraceptives for at least 6 months.