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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
The risk of these two cases is assessed through the RPN number which would combine the Severity (quantifies the severity of the failure when mitigating action is taken) and the Detection which quantifies the risk that the mitigating action is not taken.
The frequency of bodily injury claims has been relatively stable before and after the recession, but severity is still increasing.
When the F- test was significant at the 5% level, a regression analysis between the independent variable of the severity of downy mildew on leaves at the R5.
Using this modified index, the severity of pancreatitis for each patient was then categorized as mild (0-2 points), moderate (4-6 points), or severe (8-10 points).
Pairing severity identification with business process can yield even greater results.
The investigators are performing additional analyses to determine whether disease severity at different times - early versus late pregnancy has a similar or differing impact, and to assess any effect of a change in severity during pregnancy.
Type and use of safety belt bore a direct relationship to severity of crash.
Preexisting GERD was associated with increased bronchiolitis severity and increased recurrent wheezing illness at 2 years, at which time 69% of infants with GERD and 46% of those without GERD had experienced wheeze since initial study enrollment (OR, 2.
Also, use of escitalopram significantly reduced hot flash severity compared with placebo, adjusted for race, site, and baseline severity.
That severity level is based on age along with the number and intensity of the diagnoses placed in the secondary diagnosis categories in the UB-04 Bill submitted to Medicare.
The EPR3 has made a distinction between classifying asthma severity and monitoring asthma control for three sub-groups of asthma patients based on age: 0 to 4 years, 5 to 11 years, and 12 years and older.
The Fuzzy rules, which are used for evaluation of severity indices of post-contingent quantities of line loadings are