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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
The industrial sector of Punjab has suffered the most due to worst load shedding and suspension of gas supply which is getting severer by each passing day.
3 (Xinhua-ANI): A severer ban on off-base drinking issued Sunday by U.
05) as the duration of feed restriction increased and restriction for 2 weeks severer than for 1 week, which was not significantly different (P>0.
Chang said compared with the 2008-2009 economic meltdown and the 1990s Asian financial crisis the ongoing downturn is relatively severer to Taiwan's economy because it has dragged down the island's exports.
The severer occurrence of insect pests over 2011 and increasing export volume are the major factors promoting the demand for pesticides, which also raises pesticide manufacturers' previous expectation of large pesticide consumption in 2012.
What safeguards are in place to prevent severer charges from being brought against people with substance use disorders than against people who do not have addictions but committed the same crime?
Antiochia, Laodicea und Sidon in der Politik der Severer.
Distributed denial of service (DDoS) attacks brought severer threats(SUN Chang-hua, LIU Bin, 2009).
He went on to say: "It's severer than the regular one and causes extreme suffocation that in some cases leads to epilepsy .
As Islamabad quits the IMF Stand By Arrangement package and starts Fund's repayment in early 2012, much severer strains will hit the BOP.