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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
Furthermore, as Table 1 shows that the values obtained in the front direction do not differ from those obtained in the right or left directions (the dominant and nondominant sides in the controls and the symptomatically milder and severer sides in the PD patients [right SS: left SS = 9: 18]), the values are also assumed to be free from the effects of the order of measurement.
Smallpox was not to be successfully treated until Edward Jenner (1749-1823) inductively pioneered the technique of vaccination at the end of the eighteenth century by examining (or as we might now say "interrogating") the folk-lore that milkmaids were pretty: in fact, their faces were likely to be much less disfigured than those of their unfortunate contemporaries because not only had they contracted the much less devastating "cowpox" but (crucially) this gave them natural immunity to the severer disease.
On May 7, he told parliamentarians that the more weapons would be supplies to Syria the severer reaction will be.
3 (Xinhua-ANI): A severer ban on off-base drinking issued Sunday by U.
Chang said compared with the 2008-2009 economic meltdown and the 1990s Asian financial crisis the ongoing downturn is relatively severer to Taiwan's economy because it has dragged down the island's exports.
Distributed denial of service (DDoS) attacks brought severer threats(SUN Chang-hua, LIU Bin, 2009).
He went on to say: "It's severer than the regular one and causes extreme suffocation that in some cases leads to epilepsy .
As Islamabad quits the IMF Stand By Arrangement package and starts Fund's repayment in early 2012, much severer strains will hit the BOP.
Without any prejudice one can rightly say that the impacts of the second civil war had been more severer that the first in as far as the disruption of the social lives and economic activities are concerned, with around four million people displaced from their homes and another more than two million lives lost.
The TE-mode incidence induces a severer degradation on the reflected polarization than the TM-mode incidence does.
And it is likely to face a severer re-run in near future.