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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
The severed lots were provisionally approved by the Committee of Adjustment at its Jul.
New York police said that her left foot had been severed and her other leg was badly damaged too.
We believe the cause of the fault was a company working for the racecourse using a plough which severed one of the cables.
It can also be u transplant toes severed fingers and unblock an rejoin obstr fallt It can also be used to transplant toes or severed fingers and unblock and rejoin obstructed fallopian tubes to treat infertility.
The Ruvalcabas later amended their complaint to add the Kitchins, the current owners of the severed parcel, as additional plaintiffs.
By the time the problem was finally spotted weeks later the severed tendon was beyond repair.
His right hand got severed below the elbow after it came between the machine's jaws.
The estranged husband of a mother-of-two Geeta Aulakh, who was found with horrific injuries including a severed hand, has been charged with her murder, police said.
Webber said: "She broke down on her off-fore tendon which was completely severed.
EMI later denied that the band had severed or was about to sever its links with the record label and shift to Universal.
An Australian man who waved out of a car window at two young women was expected to lose his arm yesterday after it was almost severed by another passing vehicle.
To reattach a severed limb, doctors must act swiftly.

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