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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
Doctors determined the operation was possible because the severed hand was in good condition and the cut was clean.
It was the fourth cable to be severed in the region since Feb.
However, they did not check if the tendon was severed before stitching him back up and even recorded in his notes that it was still intact.
Hours later, doctors at the hospital's plastic surgery department managed to attach the severed hand back to the arm after a six- hour operation.
Mrs Aulakh, 28, was found with fatal head injuries and her hand severed after being attacked with a sword-like weapon in Greenford, north-west London on November 16.
When it's time to reunite the severed limb with its owner, doctors quickly connect the ends of the broken bones.
Essex fire service said the man's severed limbs had been recovered in the hope surgeons would be able to save them.
A fourth rope had also been severed but a fifth rope, which lies above a trap door, had been left intact, leading to fears that the culprit was an insider who knew the layout of the bell tower.
In reality, she had a severed right arm and a partially severed right leg," he said.
In the most recent blow, one of the group's most active chapters, the Iowa Christian Coalition, severed its ties to the national group and became independent, renaming itself the Iowa Christian Alliance.
It was completely severed, and the doctors weren't sure if the veins and arteries would work again.
are, purportedly, three-dimensional illustrations of a mythical future landscape with an underclass populated by, among others, severed limbs that act autonomously; mentally challenged people who can divine water sources; and a man with a five-headed penis who, because his proletarian virility makes him a target of recently deposed leaders aiming to stem the proliferation of their former subjects, is forced to dress in drag.

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